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21 Dec - 22 Dec
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26 Dec - 28 Dec
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Our top choices for San Sebastiano hotels

Exterior
Hotel Spadari Al Duomo

Hotel Spadari Al Duomo

Hotel Spadari Al Duomo
4.0 star property
Centro Storico, 0.2 km from San Sebastiano
9.8 out of 10, Exceptional, (645)
"Best hotel in the best location with kind and attentive staff! Excellent breakfast. Comfortable bed. Bathroom (newly renovated) gorgeous! "
United States
Karen
The price is 9.151.704 ₫
10.683.150 ₫ total
includes taxes & fees
12 Jan - 13 Jan 2026
Hotel Spadari Al Duomo
Front of property
Hotel Gran Duca Di York

Hotel Gran Duca Di York

Hotel Gran Duca Di York
3.0 star property
Centro Storico, 0.2 km from San Sebastiano
9.6 out of 10, Exceptional, (548)
"Great location, quiet and friendly staff!"
United States
Anette
The price is 5.445.418 ₫
6.445.942 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Hotel Gran Duca Di York
Front of property
Room Mate Collection Giulia, Milan

Room Mate Collection Giulia, Milan

Room Mate Collection Giulia, Milan
4.0 star property
Centro Storico, 0.4 km from San Sebastiano
9.6 out of 10, Exceptional, (1002)
"Excellent stay from start to finish ."
United States
Sergey
The price is 9.103.942 ₫
10.630.766 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Room Mate Collection Giulia, Milan
Bar (on property)
Park Hyatt Milano

Park Hyatt Milano

Park Hyatt Milano
5.0 star property
Scala, 0.5 km from San Sebastiano
9.6 out of 10, Exceptional, (285)
"Great location"
United States
Lisa
The price is 35.466.704 ₫
39.629.650 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Park Hyatt Milano
Down duvets, minibar, in-room safe, blackout curtains
Speronari Suites

Speronari Suites

Speronari Suites
Centro Storico, 0.2 km from San Sebastiano
9.4 out of 10, Exceptional, (204)
"Great location."
United States
Bruce
The price is 8.118.040 ₫
9.515.307 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Speronari Suites
Exterior
Ostello Bello Milano Duomo

Ostello Bello Milano Duomo

Ostello Bello Milano Duomo
0.4 km from San Sebastiano
9.4 out of 10, Exceptional, (250)
"Everything was perfect. Awesome location. Friendly staff, would definitely stay again. "
United States
Youbi
The price is 2.767.330 ₫
3.228.946 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Ostello Bello Milano Duomo
Bar (on property)
Palazzo Touring Club Milan, A Radisson Collection Hotel

Palazzo Touring Club Milan, A Radisson Collection Hotel

Palazzo Touring Club Milan, A Radisson Collection Hotel
5.0 star property
Centro Storico, 0.4 km from San Sebastiano
9.4 out of 10, Exceptional, (190)
"Beautiful Hotrel and great Location! Breakfast was good and the room great! "
United States
Giovanna
The price is 10.840.861 ₫
12.541.223 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Palazzo Touring Club Milan, A Radisson Collection Hotel
Property entrance
Luxury Suite Milano Duomo

Luxury Suite Milano Duomo

Luxury Suite Milano Duomo
Centro Storico, 0.3 km from San Sebastiano
9.4 out of 10, Exceptional, (231)
"Beds were very comfortable, location was awesome "
United States
Nadia
The price is 6.518.523 ₫
7.755.838 ₫ total
includes taxes & fees
15 Jan - 16 Jan 2026
Luxury Suite Milano Duomo
View from property
Santa Marta Suites

Santa Marta Suites

Santa Marta Suites
Centro Storico, 0.2 km from San Sebastiano
9.4 out of 10, Exceptional, (136)
"Amazing location, amazing staff! The hotel has 5 floors, each with a suite and a hotel style room. The top floor has a terrace with views of the city. We walked everywhere during our stay. The front desk staff was fantastic, as was the restaurant. Thank you so much for a great first trip to Milano!"
United States
Brittany
Santa Marta Suites
Outdoor dining
Hotel Milano Castello

Hotel Milano Castello

Hotel Milano Castello
3.0 star property
Brera, 0.6 km from San Sebastiano
9.4 out of 10, Exceptional, (1001)
"Clean room, excellent staff and wonderful breakfast "
United States
Olga
Hotel Milano Castello
Front of property
Palazzo Segreti

Palazzo Segreti

Palazzo Segreti
4.0 star property
Brera, 0.6 km from San Sebastiano
9.4 out of 10, Exceptional, (409)
"A good aperitivo served , nice breakfast and the best shower ever. "
Australia
Sussi
The price is 6.864.601 ₫
8.167.337 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Palazzo Segreti
Design Double Room, 1 King Bed | Bathroom | Free toiletries, hair dryer, bathrobes, slippers
The Street Milano Duomo | a Design Boutique Hotel

The Street Milano Duomo | a Design Boutique Hotel

The Street Milano Duomo | a Design Boutique Hotel
4.0 star property
Centro Storico, 0.6 km from San Sebastiano
9.4 out of 10, Exceptional, (306)
"Great location for all activities "
United States
Line
The price is 7.619.417 ₫
8.997.634 ₫ total
includes taxes & fees
22 Dec - 23 Dec
The Street Milano Duomo | a Design Boutique Hotel
Exterior
Matilde Boutique Hotel, WorldHotels Elite

Matilde Boutique Hotel, WorldHotels Elite

Matilde Boutique Hotel, WorldHotels Elite
4.0 star property
Centro Storico, 0.2 km from San Sebastiano
9.2 out of 10, Wonderful, (143)
"Great room, nice staff and breakfast. Concierge team was wonderful "
United States
Karrie Ellen
Matilde Boutique Hotel, WorldHotels Elite
Exclusive Apartment, 2 Bedrooms, City View (Via Santa Maria Valle 1) | Terrace/patio
Heart Milan Apartments - San Sepolcro Duomo

Heart Milan Apartments - San Sepolcro Duomo

Heart Milan Apartments - San Sepolcro Duomo
Centro Storico, < 0.1 km from San Sebastiano
9.2 out of 10, Wonderful, (510)
"Beautiful place, amazing location. "
United States
Andre
The price is 3.655.639 ₫
4.606.665 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Heart Milan Apartments - San Sepolcro Duomo
Rooftop terrace
The Square Milano Duomo - Preferred Hotels & Resorts

The Square Milano Duomo - Preferred Hotels & Resorts

The Square Milano Duomo - Preferred Hotels & Resorts
4.0 star property
Centro Storico, 0.3 km from San Sebastiano
9.2 out of 10, Wonderful, (1000)
"Very nice hotel, nice rooms, great friendly staff, very nice location."
United States
Reem
The price is 9.248.767 ₫
10.790.074 ₫ total
includes taxes & fees
22 Dec - 23 Dec
The Square Milano Duomo - Preferred Hotels & Resorts
Exterior
Santa Marta Suites

Santa Marta Suites

Santa Marta Suites
4.0 star property
Centro Storico, 0.2 km from San Sebastiano
9.2 out of 10, Wonderful, (157)
"Super location!"
United States
Ivan
Santa Marta Suites
Courtyard
Milan Retreats Duomo

Milan Retreats Duomo

Milan Retreats Duomo
Centro Storico, 0.3 km from San Sebastiano
9.2 out of 10, Wonderful, (690)
"Great place and great apartment. I’ll come again "
United States
Mohammed
The price is 2.173.774 ₫
4.455.678 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Milan Retreats Duomo
Rooftop terrace
ODSweet Duomo Milano Hotel

ODSweet Duomo Milano Hotel

ODSweet Duomo Milano Hotel
4.0 star property
Centro Storico, 0.2 km from San Sebastiano
9.2 out of 10, Wonderful, (167)
"Great location with a nice rooftop. Great room and great staff. I recommend it. "
United States
VICTOR
The price is 10.234.529 ₫
11.874.258 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
ODSweet Duomo Milano Hotel
Deluxe Double Room, 1 Double Bed | Egyptian cotton sheets, premium bedding, minibar, in-room safe
Luxury Duomo Rooms

Luxury Duomo Rooms

Luxury Duomo Rooms
Centro Storico, 0.3 km from San Sebastiano
9.2 out of 10, Wonderful, (192)
"Excellent location, modern luxurious room, friendly and helpful staff ... perfect spot to immerse yourself in Milan's historic and shopping district."
United States
Laura
The price is 5.171.119 ₫
6.273.694 ₫ total
includes taxes & fees
15 Jan - 16 Jan 2026
Luxury Duomo Rooms
Front of property
Antica Locanda dei Mercanti

Antica Locanda dei Mercanti

Antica Locanda dei Mercanti
4.0 star property
Brera, 0.6 km from San Sebastiano
9.2 out of 10, Wonderful, (286)
"beautiful room, staff friendly, good breakfast - everything we needed for our Milan stay"
Canada
Anne Marie
The price is 5.896.644 ₫
7.102.585 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Antica Locanda dei Mercanti
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top San Sebastiano Hotel Reviews

Duomo Smart Suites

Duomo Smart Suites

10/10 Excellent
"Great experience!"
Florin 2-night trip
Posted 9 days ago
Duomo Smart Suites

Hotels near other San Sebastiano attractions

Biblioteca Ambrosiana

You can learn about the history of Milan with a visit to Biblioteca Ambrosiana. Discover the area's fascinating museums and shops.
See properties

Via Torino

During your visit to Milan, you can browse for the perfect souvenirs at Via Torino. Make time to visit the area's stunning cathedral or simply enjoy its charming cafes.
See properties

Frequently asked questions

What's the area like around San Sebastiano?
San Sebastiano is located in a historic area of Milan known for its stunning cathedral and top museums. If you're looking for a convenient place to stay, take a look at the 1290 hotels and other accommodation options you'll find within a mile.
How many hotels will I be able to find close to San Sebastiano?
Expedia has 1290 hotels and other accommodation options within a mile from San Sebastiano.
If I need to cancel the hotel reservation for my stay near San Sebastiano, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to view the best options available near San Sebastiano.
What can I see and do near San Sebastiano?
Museo del Novecento, Castello Sforzesco and Pinacoteca di Brera feature captivating exhibits. Sights like Cathedral of Milan, Biblioteca Ambrosiana and Royal Palace of Milan are must-sees while exploring the area. You can check out the local talent at Teatro alla Scala, Teatro Dal Verme and Teatro Manzoni.
How can I get to San Sebastiano?
With so many choices for transport, seeing the area around San Sebastiano is easy. You can access metro transport at Duomo Station, Via Orefici P.za Cordusio Tram Stop and Cordusio M1 Tram Stop. If you're taking a train into town, Milan Cadorna Nord Station and Milan (XNC-Cadorna Train Station) are the closest stations to Milan Centre.