Santo Spirito Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
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Historic Centre of Florence

10 out of top 10 points of interest in this area

Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Uffizi Gallery are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

Find hotels in Historic Centre of Florence

Top hotels in Santo Spirito

UNA HOTELS Vittoria Firenze

UNA HOTELS Vittoria Firenze

4 out of 5
Via Pisana 59, Florence, FI
Fully refundableReserve now, pay when you stay
The price is 2.878.479 ₫ per night from 10 Aug to 11 Aug
2.878.479 ₫
3.590.321 ₫ total
10 Aug - 11 Aug
includes taxes & fees
8.4/10 Very Good! (990 reviews)
"Amazing place, love the decor!"

Reviewed on 28 Jul 2025

UNA HOTELS Vittoria Firenze
Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13, Florence, FI
Fully refundableReserve now, pay when you stay
The price is 3.817.391 ₫ per night from 4 Aug to 5 Aug
3.817.391 ₫
4.618.330 ₫ total
4 Aug - 5 Aug
includes taxes & fees
9.6/10 Exceptional! (543 reviews)
"Excellent hotel and great hospitality! Highly recommend !"

Reviewed on 26 Jul 2025

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r, Florence, FI
9.2/10 Wonderful! (1,005 reviews)
"Great little place in the middle of old town. Nice to have a kitchen. Very walkable location. Staff was wonderful, with recommendations and very helpful with taxi transportation."

Reviewed on 23 Jul 2025

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Palazzo Mannaioni Suites
See all 469 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santo Spirito holiday package cost?
From just . Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favourite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito holiday package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1null000null000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Centre Of Florence.
How far in advance should I book my Santo Spirito holiday?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including holiday rentals like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia holiday package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our holiday packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito holiday package?
If your holiday plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

Popular places to visit

Piazza Santo Spirito

Piazza Santo Spirito

Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art galleries and stunning cathedral in this vibrant area.

Piazza Santo Spirito
Uffizi Gallery

Uffizi Gallery

Uffizi Gallery is a top museum in Florence with a rich history. Stroll along the riverfront or visit the notable monuments in this vibrant area.

Uffizi Gallery
Cathedral of Santa Maria del Fiore featuring religious elements, a church or cathedral and a city

Cathedral of Santa Maria del Fiore

Find out about the history of Cathedral of Santa Maria del Fiore, a well-known monument in Florence. Experience the fascinating museums and acclaimed art galleries in this vibrant area.

Cathedral of Santa Maria del Fiore