Search Luxury Hotels in South Carolina Midlands

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on South Carolina Midlands Luxury Hotels

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top South Carolina Midlands Luxury Hotels

View from property
The Ballantyne, A Luxury Collection Hotel, Charlotte

The Ballantyne, A Luxury Collection Hotel, Charlotte

5.0 star property
Ballantyne
9.4 out of 10, Exceptional, (1003)
"This hotel is always amazing I find it so welcoming and relaxing. "
United States
David
The price is 7.548.744 ₫
8.699.928 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The Ballantyne, A Luxury Collection Hotel, Charlotte
Front of property
The Willcox

The Willcox

3.5 star property
Aiken
9.6 out of 10, Exceptional, (142)
"Wonderful stay all around."
United States
Anastasija
The price is 7.551.909 ₫
8.458.349 ₫ total
includes taxes & fees
17 Dec - 18 Dec
The Willcox
Rooftop terrace
The Mantissa Hotel

The Mantissa Hotel

3.0 star property
Hartsville
9.2 out of 10, Wonderful, (269)
"Very nice spacious rooms friendly staff"
United States
Duane
The price is 4.272.426 ₫
4.785.118 ₫ total
includes taxes & fees
10 Dec - 11 Dec
The Mantissa Hotel
Breakfast area
Travelodge by Wyndham Orangeburg

Travelodge by Wyndham Orangeburg

2.0 star property
Orangeburg
8.2 out of 10, Very good, (1000)
"Enjoyed our stay "
Australia
Marie
The price is 1.770.947 ₫
1.965.753 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Travelodge by Wyndham Orangeburg
View from property
Carriage House Inn

Carriage House Inn

3.0 star property
Aiken
9.4 out of 10, Exceptional, (460)
"Friendly and helpful staff that truly make you feel like a priority. Beautiful historic/boutique hotel in the heart of downtown Aiken. 10/10 will stay here again! "
United States
Evan
The price is 5.248.227 ₫
5.878.014 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Carriage House Inn
Free daily continental breakfast
Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

2.0 star property
Rock Hill
7.0 out of 10, Good, (1001)
"Quiet and affordable "
United States
Tyler
The price is 1.513.810 ₫
1.680.328 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
Property entrance
Inn on the Square, an Ascend Collection Hotel

Inn on the Square, an Ascend Collection Hotel

3.0 star property
Uptown Greenwood
9.2 out of 10, Wonderful, (707)
"It was a very clean and beautiful lace to stay. We were there for our honeymoon "
United States
Tracy
The price is 2.880.941 ₫
3.197.847 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Inn on the Square, an Ascend Collection Hotel
Restaurant
Sheraton Columbia Downtown Hotel

Sheraton Columbia Downtown Hotel

3.5 star property
Downtown Columbia
8.4 out of 10, Very good, (1001)
"Clean rooms and hospitable staff!"
United States
James
The price is 3.112.014 ₫
3.485.455 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Sheraton Columbia Downtown Hotel
Seasonal outdoor pool, open 10 AM to 9:00 PM, pool loungers
Baymont by Wyndham Greenwood

Baymont by Wyndham Greenwood

2.5 star property
Greenwood
7.6 out of 10, Good, (764)
"Was perfect for one stay, and located close to my Buinness meeting "
United States
Raymond C
The price is 1.856.659 ₫
2.060.892 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Baymont by Wyndham Greenwood
Lobby
Red Roof Inn Santee

Red Roof Inn Santee

2.0 star property
Santee
6.6 out of 10, (637)
"It's a good stop for the price "
United States
Martin
Red Roof Inn Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top South Carolina Midlands Hotel Reviews

Explore a world of travel with Expedia