Find hotels in Defiance, MO from 1.883.646 ₫

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Our top choices for Defiance hotels

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,117 reviews)
"Great room, great people, great breakfast "
United States
Jaiden
The price is 2.337.368 ₫
2.699.562 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (947 reviews)
"Clean rooms, pleasant staff."
United States
Karen
The price is 1.782.552 ₫
2.013.393 ₫ total
includes taxes & fees
22 Mar - 23 Mar
Quality Inn Foristell

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,002 reviews)
"Nice place and nice people "
United States
Columbus
The price is 1.939.836 ₫
2.215.778 ₫ total
includes taxes & fees
9 Mar - 10 Mar
Baymont by Wyndham Warrenton

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
8.0 out of 10, Very good, (1,152 reviews)
"Clean rooms, quiet, AC worked great and good breakfast "
United States
Karen
The price is 2.072.217 ₫
2.393.161 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Wingate by Wyndham St. Louis/Fenton Route 66

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.0 out of 10, Wonderful, (48 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is 2.330.821 ₫
2.759.656 ₫ total
includes taxes & fees
13 Mar - 14 Mar
WoodSpring Suites St Peters-OFallon

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,009 reviews)
"Friendly staff, clean room, comfy bed, excellent breakfast buffet."
United States
Kathy
The price is 2.074.169 ₫
2.446.482 ₫ total
includes taxes & fees
15 Mar - 16 Mar
Sleep Inn & Suites O'Fallon MO - Technology Drive

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,633 reviews)
"Clean room and great breakfast "
United States
Shawn
The Wildwood Hotel

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (222 reviews)
"Stay was great, and the pool was perfect for my daughter and her friend. Wonderful spot for an easy "stay cation" with the girls. "
United States
Melissa
The price is 2.390.717 ₫
2.760.992 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Best Western Plus Fenton

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,004 reviews)
"Great hotel for the money"
United States
Jere
The price is 2.283.764 ₫
2.624.662 ₫ total
includes taxes & fees
15 Mar - 16 Mar
Comfort Suites St Charles - St Louis

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (663 reviews)
"Clean room and hotel with a nice breakfast, have stayed here two times while visiting family."
United States
Brooks
The price is 3.378.381 ₫
3.846.287 ₫ total
includes taxes & fees
5 Apr - 6 Apr
Best Western Plus Washington Hotel

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very good, (1,003 reviews)
"Great place to stay for the $$$"
United States
Kale
The price is 2.094.761 ₫
2.407.445 ₫ total
includes taxes & fees
15 Mar - 16 Mar
Super 8 by Wyndham St Charles

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (366 reviews)
"Excellent staff & very clean room"
United States
Karen
The price is 2.592.711 ₫
2.968.006 ₫ total
includes taxes & fees
10 Mar - 11 Mar
Quality Inn Near Six Flags St. Louis

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,003 reviews)
"Comfortable room. Quiet even though next to interstate. Excellent food "
United States
Geo
The price is 2.883.278 ₫
3.314.326 ₫ total
includes taxes & fees
15 Mar - 16 Mar
Drury Inn & Suites St. Louis St. Peters

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (666 reviews)
"Prompt service, quick check in. "
United States
Emily
The price is 3.121.729 ₫
3.572.819 ₫ total
includes taxes & fees
15 Mar - 16 Mar
Hampton Inn St. Louis Wentzville

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (874 reviews)
"Beautiful hotel, friendly staff, good breakfast."
United States
Erika
The price is 3.475.976 ₫
4.144.084 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
3.0 star property
Eureka
9.0 out of 10, Wonderful, (1,000 reviews)
"Clean rooms and kids really enjoyed the pool area."
United States
VeAnn
The price is 3.040.824 ₫
3.542.195 ₫ total
includes taxes & fees
10 Mar - 11 Mar
Holiday Inn St. Louis West Six Flags by IHG

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (659 reviews)
"Hotel staff was friendly and room was very clean "
United States
Danielle
The price is 3.352.246 ₫
3.836.647 ₫ total
includes taxes & fees
12 Mar - 13 Mar
Fairfield Inn & Suites Wentzville

River Sirens Hotel

River Sirens Hotel
2.5 star property
Washington
9.8 out of 10, Exceptional, (191 reviews)
"The room was amazing!!! Would definitely stay again "
United States
Katharine
River Sirens Hotel

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,003 reviews)
"Great location and friendly staff "
United States
Heather
The price is 2.643.944 ₫
3.038.605 ₫ total
includes taxes & fees
5 Apr - 6 Apr
Hampton Inn St. Charles St. Peters

Cedar Creek

Cedar Creek
3.0 star property
New Haven
9.0 out of 10, Wonderful, (265 reviews)
"We got a surprise upgrade to our room. The cottage was beautiful and clean. The staff was perfect."
United States
Joan
Cedar Creek
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

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Frequently asked questions

What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.