Photo by Rebecca Friedland

Search Hotels Near UCSF Mission Bay, San Francisco

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
23 Dec - 24 Dec
Tomorrow
24 Dec - 25 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for UCSF Mission Bay hotels

Tapas bar
LUMA Hotel San Francisco

LUMA Hotel San Francisco

LUMA Hotel San Francisco
4.0 star property
0.7 km from UCSF Mission Bay
9.6 out of 10, Exceptional, (2393)
"Staff were so nice, the rooms were clean will definitely come back "
United States
Karla
The price is 5.134.935 ₫
6.043.563 ₫ total
includes taxes & fees
24 Dec - 25 Dec
LUMA Hotel San Francisco
Terrace/patio
Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown
3.0 star property
1.1 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1880)
"Great stay. "
United States
Jon
The price is 3.923.617 ₫
4.617.902 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Hyatt Place San Francisco Downtown
Property entrance
Hotel VIA

Hotel VIA

Hotel VIA
4.0 star property
1.2 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1505)
"The staff was amazing and made my stay feel good. "
United States
Omaly
The price is 4.242.246 ₫
4.992.911 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hotel VIA
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
2.6 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (3093)
"Great hotel, great location, super friendly all staff "
Mexico
Claudia
The price is 1.994.460 ₫
2.356.658 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Chancellor Hotel on Union Square
Daily buffet breakfast (USD 22 per person)
citizenM San Francisco Union Square

citizenM San Francisco Union Square

citizenM San Francisco Union Square
4.0 star property
Union Square, 2.3 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (1431)
"Great service, great room!!"
United States
Arlindo
The price is 3.133.627 ₫
3.688.122 ₫ total
includes taxes & fees
24 Dec - 25 Dec
citizenM San Francisco Union Square
Exterior
The St. Regis San Francisco

The St. Regis San Francisco

The St. Regis San Francisco
5.0 star property
South of Market, 2.1 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (696)
"Impeccable service; nice room, overall great experience"
United States
Karla
The price is 9.716.877 ₫
12.636.325 ₫ total
includes taxes & fees
26 Dec - 27 Dec
The St. Regis San Francisco
Exterior
Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
South of Market, 2.2 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (1304)
"Very nice and view was incredible "
United States
Morgan
The price is 4.134.281 ₫
5.916.528 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hyatt Regency San Francisco Downtown SOMA
Exterior
InterContinental San Francisco by IHG

InterContinental San Francisco by IHG

InterContinental San Francisco by IHG
4.0 star property
South of Market, 1.8 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1036)
"Great stay as always "
United States
JoAnn
The price is 4.118.481 ₫
5.932.165 ₫ total
includes taxes & fees
25 Dec - 26 Dec
InterContinental San Francisco by IHG
Indoor pool
Hotel Nikko San Francisco

Hotel Nikko San Francisco

Hotel Nikko San Francisco
4.5 star property
Union Square, 2.4 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (2659)
"Great service, great location, great hotel. "
United States
Laura
The price is 4.003.827 ₫
5.922.191 ₫ total
includes taxes & fees
23 Jan - 24 Jan 2026
Hotel Nikko San Francisco
Lobby
Galleria Park Hotel

Galleria Park Hotel

Galleria Park Hotel
4.0 star property
Financial District, 2.5 km from UCSF Mission Bay
9.6 out of 10, Exceptional, (1012)
"I had a great stay. The room was nice, the bed was comfortable, and the staff were very helpful."
United States
Luke
The price is 3.099.657 ₫
4.732.797 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Galleria Park Hotel
Property entrance
Orchard Garden Hotel

Orchard Garden Hotel

Orchard Garden Hotel
4.0 star property
Chinatown, 2.7 km from UCSF Mission Bay
9.6 out of 10, Exceptional, (1004)
"Had a really good time here the room was so comfortable and there’s lots to eat in the neighborhood and very walkable. The staff was so sweet and had good recommendations "
United States
Natasha
The price is 3.673.453 ₫
4.382.140 ₫ total
includes taxes & fees
16 Jan - 17 Jan 2026
Orchard Garden Hotel
Terrace/patio
Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco
5.0 star property
South of Market, 2.2 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (1005)
"Clean rooms , Safety and helpful staff members "
United States
Christina
The price is 10.138.205 ₫
11.932.009 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Four Seasons Hotel San Francisco
3 bars/lounges
Canopy by Hilton San Francisco SoMa

Canopy by Hilton San Francisco SoMa

Canopy by Hilton San Francisco SoMa
4.0 star property
South Park, 1.7 km from UCSF Mission Bay
9.0 out of 10, Wonderful, (1004)
"Good room , good service, good location "
United States
Albina
The price is 4.137.968 ₫
4.870.181 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Canopy by Hilton San Francisco SoMa
Lobby
The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott
4.0 star property
South Park, 1.9 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1004)
"cleanliness,good service, convenient location"
United States
Harry
The price is 4.215.387 ₫
6.052.482 ₫ total
includes taxes & fees
30 Dec - 31 Dec
The Clancy, Autograph Collection by Marriott
Exterior
W San Francisco

W San Francisco

W San Francisco
4.5 star property
South Park, 2 km from UCSF Mission Bay
9.0 out of 10, Wonderful, (1008)
"Great location and good accommodations "
United States
Michael
The price is 4.186.947 ₫
5.858.368 ₫ total
includes taxes & fees
30 Dec - 31 Dec
W San Francisco
55-inch TV with digital channels, pay films
The Clift Royal Sonesta San Francisco

The Clift Royal Sonesta San Francisco

The Clift Royal Sonesta San Francisco
4.0 star property
2.6 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1368)
"Staff was amazing. The rooms felt clean and the hotel was very well maintained."
United States
Misty
The price is 3.531.255 ₫
5.183.097 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
The Clift Royal Sonesta San Francisco
View from property
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco
5.0 star property
Financial District, 2.4 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1005)
"Just a spectacular place to stay! Beautifully appointed. All staff were very friendly and accommodating We will definitely be back!"
United States
Mandana
The price is 7.086.210 ₫
8.340.114 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Palace Hotel, a Luxury Collection Hotel, San Francisco
Lobby
Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel
4.0 star property
Union Square, 2.6 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1821)
"Amazing place"
Australia
David
The price is 3.617.425 ₫
5.342.184 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Beacon Grand, A Union Square Hotel
Breakfast and dinner served
Hotel Zelos San Francisco

Hotel Zelos San Francisco

Hotel Zelos San Francisco
4.0 star property
South of Market, 2.2 km from UCSF Mission Bay
9.0 out of 10, Wonderful, (1106)
"Clean room, friendly staff, convenient location. "
United States
Elizabeth
The price is 3.827.238 ₫
5.589.123 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Zelos San Francisco
Premium bedding, pillow-top beds, in-room safe, desk
Inn At Union Square

Inn At Union Square

Inn At Union Square
3.5 star property
2.6 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1012)
"Everything was perfect location staff room and that continental breakfast was delicious Thankyou "
United Kingdom
robert
The price is 2.820.264 ₫
3.977.635 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Inn At Union Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top UCSF Mission Bay Hotel Reviews

Hotels near other UCSF Mission Bay attractions

Chase Center San Francisco Skyline Aerial Photography

Chase Center

Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its entertainment choices.
See properties
Anchor Brewing Company

Anchor Brewing Company

During your trip to San Francisco, you can do some window-shopping at Anchor Brewing Company. Discover the top-notch restaurants and acclaimed art galleries in this vibrant area.
See properties

Frequently asked questions

What's the area like around UCSF Mission Bay?
UCSF Mission Bay is located in a vibrant area of San Francisco known for its top museums and stunning architecture. If you're looking for a convenient place to stay, take a look at the 85 hotels and other accommodation options you'll find within a mile.
How many hotels will I be able to find close to UCSF Mission Bay?
Expedia has 85 hotels and other accommodation options within a mile from UCSF Mission Bay.
If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Add dates, click "Search", then use the filter option "fully refundable" to view top deals close to UCSF Mission Bay.
What can I see and do near UCSF Mission Bay?
Study the collections at San Francisco Museum of Modern Art, Asian Art Museum of San Francisco or Market Street Railway Museum. Sights like San Francisco Mint, 450 Sutter Building and Ferry Building are landmarks to visit in the area. You can check out the local talent at Golden Gate Theatre, Warfield Theatre and Orpheum Theatre.
How can I get to UCSF Mission Bay?
With so many choices for transport, seeing all of the area near UCSF Mission Bay is simple. You can access metro transport at Market St & 5th St Stop, Market St & Taylor St Stop and Powell St & Market St Stop. If you're hopping a train into the city, San Francisco Station is the closest station to Downtown San Francisco.