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Check availability on West Main Historic District Luxury Hotels

Our top choices for West Main Historic District luxury hotels

Deluxe Single Room, 1 King Bed, River View | View from room
The Grady

The Grady

4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1005)
"The location was outstanding and atmosphere was very nice."
United States
Malcolm
The price is 3.819.854 ₫
4.494.441 ₫ total
includes taxes & fees
16 Dec - 17 Dec
The Grady
Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1715)
"Clean room, friendly staff"
United States
Jill
The price is 4.407.938 ₫
5.186.380 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Omni Louisville Hotel
Exterior
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (428)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is 4.616.777 ₫
5.432.099 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Hotel Distil, Autograph Collection
Restaurant
Louisville Marriott Downtown

Louisville Marriott Downtown

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1001)
"Very nice hotel. Great stay!"
United States
Brad
The price is 4.511.593 ₫
5.308.340 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Louisville Marriott Downtown
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1000)
" Loved our stay, would definitely plan to come back if we are ever in the area again."
United States
Erica
The price is 3.664.318 ₫
4.443.579 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
21c Museum Hotel Louisville
4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (3838)
"Beautiful room and great hospitality. "
United States
Chase
The price is 3.514.055 ₫
4.134.636 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Galt House Hotel Trademark Collection by Wyndham
Breakfast, lunch and dinner served
Hyatt Regency Louisville

Hyatt Regency Louisville

4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1005)
"Enjoyed our stay "
United States
Jedediah
The price is 3.015.813 ₫
3.548.405 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Hyatt Regency Louisville
Dinner served
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1105)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is 2.931.454 ₫
3.449.149 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Embassy Suites Louisville Downtown
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (52)
"Lovely hotel in downtown Louisville. Well appointed room, comfy bed and outstanding dining. "
United States
Michelle
The price is 3.786.901 ₫
4.455.667 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Lobby
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1002)
"Excellent location and a great lobby bar with a top notch bourbon selection. "
United States
vincent
The price is 3.025.154 ₫
3.559.397 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Seelbach Hilton Louisville Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top West Main Historic District Hotel Reviews

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Frequently asked questions

Are you looking for a luxury hotel for your stay in West Main Historic District?
During your visit, you might want to enjoy the art and theatre which West Main Historic District is known for.
What's there to see and do in West Main Historic District?
Take in the sights and attractions that West Main Historic District offers with a visit to Frazier International History Museum, Louisville Slugger Museum and Louisville Science Center. If you have extra time while you're in the area, you might want to see 21c Museum Hotel and Muhammad Ali Center.