Compare and book 4 Star hotels in Serra Mesa, San Diego

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Check availability on Serra Mesa 4 Star Hotels

Our top choices for Serra Mesa 4-star hotels

Lobby
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton
4.0 star property
Historic Downtown Coronado
8.4 out of 10, Very good, (1007)
"Beautiful rooms, great activities, wonderful staff "
United States
Kyle
The price is 8.943.385 ₫
11.392.802 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel del Coronado, Curio Collection by Hilton
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (3142)
"Great stay"
United States
Laurence
The price is 4.484.176 ₫
6.410.975 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hard Rock Hotel San Diego
Daily buffet breakfast for a fee
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley
4.0 star property
Mission Valley
8.4 out of 10, Very good, (1397)
"Great hotel in a great area - would definitely stay here again."
United States
Bhupinder
The price is 3.113.770 ₫
3.579.123 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (80)
"It was a nice place to stay at"
United States
Eric
The price is 2.899.820 ₫
3.362.197 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Courtyard by Marriott San Diego Downtown Little Italy
Lobby
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

Hilton San Diego Mission Valley
4.0 star property
Mission Valley
8.0 out of 10, Very good, (2239)
"Excelente hotel"
Mexico
Julio
The price is 3.114.670 ₫
3.580.157 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hilton San Diego Mission Valley
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2958)
"Everything was super comfortable and the room was surprisingly affordable for the amenities you get. We will definitely stay there again if we go to San Diego."
United States
Eric
The price is 4.012.195 ₫
4.611.818 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Legacy Resort Hotel & Spa
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
Downtown San Diego
8.4 out of 10, Very good, (6039)
"Always an amazing stay"
United States
Jana
The price is 3.563.906 ₫
4.896.902 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Wyndham San Diego Bayside
Lobby
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1541)
"Clean room, friendly staff, great property. "
United States
MIGUEL
The price is 4.303.584 ₫
5.946.495 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Embassy Suites by Hilton San Diego Bay Downtown
Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)
Lafayette Hotel & Club

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (1321)
"My wife loved everything about this vintage hotel."
United States
Eddie
The price is 5.957.812 ₫
6.836.589 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Lafayette Hotel & Club
Outdoor pool
Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel
4.0 star property
Mission Valley
8.6 out of 10, Excellent, (1650)
"Decent room, great staff and close to am"
United States
siva
The price is 3.111.660 ₫
3.576.698 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Sheraton Mission Valley San Diego Hotel
Terrace/patio
Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla
4.0 star property
University City
8.8 out of 10, Excellent, (1774)
"Good hot food!!"
United States
Cris
The price is 3.987.144 ₫
4.583.023 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Embassy Suites by Hilton San Diego La Jolla
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1057)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.565.224 ₫
4.898.165 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Hypo-allergenic bedding, in-room safe, desk, iron/ironing board
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (2868)
"It was nice and the bar up top was great"
United States
Brent
The price is 4.639.712 ₫
6.815.895 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Manchester Grand Hyatt San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1941)
"Great hotel"
United States
Farzana
The price is 4.192.830 ₫
6.248.174 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Marriott Marquis San Diego Marina
Courtyard
DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar
4.0 star property
Carmel Valley
8.4 out of 10, Very good, (1865)
"The room had a great view of the pool and staff was very friendly! "
United States
eva
The price is 3.220.909 ₫
3.670.065 ₫ total
includes taxes & fees
21 Dec - 22 Dec
DoubleTree by Hilton San Diego - Del Mar
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1160)
"Amenities and location were great. "
United States
Julie
The price is 4.248.207 ₫
5.995.678 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
Property amenity
San Diego Marriott Mission Valley

San Diego Marriott Mission Valley

San Diego Marriott Mission Valley
4.0 star property
Mission Valley
8.8 out of 10, Excellent, (1005)
"Great room and staff"
United States
Mario
The price is 3.665.430 ₫
4.213.228 ₫ total
includes taxes & fees
14 Dec - 15 Dec
San Diego Marriott Mission Valley
Lobby sitting area
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (2048)
"It was an amazing stay "
United States
Alejandra
The price is 4.909.000 ₫
6.884.191 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Omni San Diego Hotel at the Ballpark
Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.2 out of 10, Very good, (3172)
"Great stay! "
United States
Melissa
The price is 2.478.780 ₫
3.798.554 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Sheraton San Diego Resort
Exterior
InterContinental San Diego by IHG

InterContinental San Diego by IHG

InterContinental San Diego by IHG
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1113)
"Excellent location prior to a cruise."
Canada
Joan
The price is 5.669.550 ₫
8.103.020 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
InterContinental San Diego by IHG
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Serra Mesa.
Pendry San Diego

Pendry San Diego

550 J Street San Diego CA
The price is 6.724.350 ₫ per night from 4 Jan to 5 Jan
6.724.350 ₫
per night
4 Jan - 5 Jan
9.2/10 Wonderful! (1,000 reviews)
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PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Serra Mesa Hotel Reviews

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Hotel was great, no regrets at all."
Gabriel 2-night trip
Posted 5 days ago
Courtyard by Marriott San Diego Downtown Little Italy

Frequently asked questions

What are the best 4-star hotels in Serra Mesa?
Enjoy the quality and comfort of San Diego Marriott Mission Valley. This 4-star hotel around Serra Mesa is highly recommended by many Expedia guests and comes with concierge services and a terrace. Another sought-after choice in or near this neighbourhood is DoubleTree by Hilton Hotel San Diego - Mission Valley. Premium bedding and designer toiletries help make it popular.
How much does it cost to stay in a 4-star hotel in Serra Mesa?
Expedia can help you quickly locate the ideal 4-star hotel for your stay in Serra Mesa. Use our filter tool to tailor your search by things like price, amenities and hotel star rating and get access to awesome deals in a few clicks.

  • Search for the lowest price from 7.522.905 ₫

What's the difference between 5-star and 4-star hotels in Serra Mesa?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Serra Mesa holiday. These kinds of stays generally feature lots of useful amenities that make it a breeze to unpack and relax — think 24-hour room service, restaurants and pools. Or enjoy even more lavishness at a 5-star hotel designed to pamper with exclusive perks and amenities. Concierge assistance, premium toiletries and gourmet dining are typically featured at these deluxe properties.

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