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Search Hotels in Downtown Clayton, St. Louis

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21 Dec - 22 Dec
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Our top choices for Downtown Clayton hotels

Property entrance
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 star property
Downtown Clayton
8.4 out of 10, Very good, (577)
"Love this place."
United States
Robert
The price is 3.210.430 ₫
3.997.007 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Outdoor pool, open 8:00 AM to 8:30 PM, pool umbrellas, pool loungers
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Downtown Clayton
8.8 out of 10, Excellent, (681)
"Small rooms but beautiful lobby. "
United States
Debbie
The price is 3.136.748 ₫
3.693.145 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Le Méridien St. Louis Clayton
2 bars/lounges, rooftop bar
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton
3.0 star property
Downtown Clayton
9.0 out of 10, Wonderful, (224)
"Enjoyed my stay"
United States
Kingsley
The price is 3.210.430 ₫
3.747.791 ₫ total
includes taxes & fees
28 Dec - 29 Dec
AC Hotel St. Louis Clayton
Meeting facility
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Downtown Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
The price is 13.131.185 ₫
15.329.082 ₫ total
includes taxes & fees
22 Dec - 23 Dec
The Ritz-Carlton, St. Louis
Exterior
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Downtown Clayton
8.8 out of 10, Excellent, (3037)
"Clean room, good breakfast and good location "
United States
Martin
The price is 2.479.031 ₫
2.893.971 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Clayton Plaza Hotel & Extended Stay
Meeting facility
Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO
2.0 star property
14.6 km from Downtown Clayton
8.4 out of 10, Very good, (1630)
"Great stay!"
United States
Ambrose
The price is 1.574.690 ₫
1.924.869 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Motel 6 Hazelwood, MO
Terrace/patio
Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia
2.5 star property
25.3 km from Downtown Clayton
8.6 out of 10, Excellent, (476)
"Breakfast was great and a very good atten"
United States
John
The price is 2.587.028 ₫
2.871.084 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Hampton Inn St. Louis - Columbia
Exterior
The Principal Hotel

The Principal Hotel

The Principal Hotel
3.5 star property
26 km from Downtown Clayton
9.8 out of 10, Exceptional, (193)
"Great place. Very nice rooms, new and clean."
United States
Jeff
The price is 2.968.595 ₫
3.294.638 ₫ total
includes taxes & fees
22 Dec - 23 Dec
The Principal Hotel
Terrace/patio
Courtyard by Marriott St. Louis St. Peters

Courtyard by Marriott St. Louis St. Peters

Courtyard by Marriott St. Louis St. Peters
3.0 star property
26.6 km from Downtown Clayton
9.0 out of 10, Wonderful, (648)
"Great stay!"
United States
Travis
The price is 2.973.595 ₫
3.549.721 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Courtyard by Marriott St. Louis St. Peters
Indoor pool
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station
3.0 star property
Downtown West, 11.3 km from Downtown Clayton
9.4 out of 10, Exceptional, (1300)
"Nice hotel"
United States
Vivian
The price is 3.131.222 ₫
3.723.836 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Drury Inn & Suites St. Louis Union Station
Lobby
Casino Queen Hotel

Casino Queen Hotel

Casino Queen Hotel
3.0 star property
14.2 km from Downtown Clayton
7.6 out of 10, Good, (1976)
"Clean and comfortable room, pleasant staff."
United States
Bradley
The price is 2.214.407 ₫
2.568.269 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Casino Queen Hotel
Exterior
SpringHill Suites St. Louis Brentwood

SpringHill Suites St. Louis Brentwood

SpringHill Suites St. Louis Brentwood
3.0 star property
2.9 km from Downtown Clayton
9.0 out of 10, Wonderful, (1001)
"Really liked the room--very spacious with a lot of room to spread out. Excellent breakfast! Note that parking is $10/night. I missed that when looking for a St. Louis hotel. "
United States
Leslie
The price is 2.947.280 ₫
3.477.436 ₫ total
includes taxes & fees
28 Dec - 29 Dec
SpringHill Suites St. Louis Brentwood
Exterior
Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis, 12.9 km from Downtown Clayton
8.8 out of 10, Excellent, (1243)
"Great hospitality"
United States
Alejandro
The price is 2.891.492 ₫
3.438.821 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Embassy Suites by Hilton St. Louis Downtown
Exterior
Fairfield Inn & Suites St Louis Westport

Fairfield Inn & Suites St Louis Westport

Fairfield Inn & Suites St Louis Westport
2.5 star property
10.7 km from Downtown Clayton
9.2 out of 10, Wonderful, (810)
"Everything was great "
United States
Alan
The price is 3.109.117 ₫
3.606.202 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Fairfield Inn & Suites St Louis Westport
Exterior
Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch
4.0 star property
Downtown St. Louis, 13.1 km from Downtown Clayton
8.8 out of 10, Excellent, (1018)
"My second time staying there as always it was lovely "
United States
Nina
The price is 2.715.708 ₫
3.202.607 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Hilton Pennywell St. Louis at the Arch
Breakfast and dinner served, American cuisine
Courtyard by Marriott St. Louis Downtown West

Courtyard by Marriott St. Louis Downtown West

Courtyard by Marriott St. Louis Downtown West
3.0 star property
Downtown West, 10.8 km from Downtown Clayton
8.6 out of 10, Excellent, (1000)
"Yes … room clean and staff very helpful"
United States
Jim
The price is 2.997.278 ₫
3.504.687 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Courtyard by Marriott St. Louis Downtown West
Terrace/patio
Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport
2.5 star property
9.9 km from Downtown Clayton
8.8 out of 10, Excellent, (103)
"Great stay for the night before our trip"
United States
April
The price is 3.215.167 ₫
3.836.915 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Hampton Inn By Hilton St Louis Airport
Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
19 km from Downtown Clayton
8.4 out of 10, Very good, (1000)
"Nice staff at reception. "
United States
Denise
The price is 2.011.255 ₫
2.311.475 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Comfort Suites St Charles - St Louis
Suite, 1 Bedroom, City View | Living room | Smart TV, Netflix
Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center
3.0 star property
Downtown St. Louis, 12.7 km from Downtown Clayton
9.0 out of 10, Wonderful, (1001)
"Was a great stay. "
United States
Lorilyn
The price is 2.549.924 ₫
3.032.600 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Courtyard by Marriott St. Louis Downtown/Convention Center
Indoor pool, open 6:00 AM to 10:00 PM, pool loungers
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
2.5 star property
Downtown St. Louis, 13.2 km from Downtown Clayton
8.8 out of 10, Excellent, (1180)
"Breakfast was great and this was my seventh year staying there."
United States
Derick
The price is 2.567.818 ₫
3.002.524 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown Clayton

Find the best Downtown Clayton areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Central West End

Central West End

If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Top Downtown Clayton Hotel Reviews

Frequently asked questions

What's it like in Downtown Clayton?
Travellers to the Downtown Clayton neighbourhood in St. Louis will be sure to enjoy their stay.
How many hotels can I expect to find in the Downtown Clayton area?
Expedia has 5 Downtown Clayton hotels and other accommodation options, and one might make a good home base for venturing out into the greater St. Louis area.
If I need to cancel my hotel reservation in Downtown Clayton, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the top deals on offer in Downtown Clayton.
What can I see and do in this St. Louis neighbourhood?
Shaw Park Tennis Center, Saint Louis Galleria Mall and Tao Tennis Center are just a few of the places to visit in and around Downtown Clayton. While you're out sightseeing, Center of Creative Arts and Chapel of St. Timothy And St. Titus, Concordia Seminary are a couple of additional sights to visit in St. Louis.
How can I get around Downtown Clayton and the greater St. Louis area?
Ready to get out and explore the city? Clayton Station is the closest metro station.