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Search Hotels in Downtown Clayton, St. Louis

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10 Dec - 11 Dec
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Our top choices for Downtown Clayton hotels

Exterior
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Downtown Clayton
8.8 out of 10, Excellent, (3028)
"Clean room, good breakfast and good location "
United States
Martin
The price is 2.393.605 ₫
2.794.429 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Clayton Plaza Hotel & Extended Stay
2 bars/lounges, rooftop bar
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton
3.0 star property
Downtown Clayton
9.2 out of 10, Wonderful, (222)
"Enjoyed my stay"
United States
Kingsley
The price is 3.216.164 ₫
3.754.486 ₫ total
includes taxes & fees
21 Dec - 22 Dec
AC Hotel St. Louis Clayton
Meeting facility
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Downtown Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
The price is 13.154.638 ₫
15.356.392 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Ritz-Carlton, St. Louis
Outdoor pool, open 8:00 AM to 8:30 PM, pool umbrellas, pool loungers
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Downtown Clayton
8.8 out of 10, Excellent, (675)
"Small rooms but beautiful lobby. "
United States
Debbie
The price is 3.142.350 ₫
3.699.741 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Le Méridien St. Louis Clayton
Property entrance
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 star property
Downtown Clayton
8.4 out of 10, Very good, (577)
"Love this place."
United States
Robert
The price is 3.216.164 ₫
4.004.147 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Rooftop terrace
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
Downtown St. Louis, 13.1 km from Downtown Clayton
9.4 out of 10, Exceptional, (3279)
"Our stay was very enjoyable. Location was great and kids loved the indoor pool!"
United States
Christy
The price is 3.558.606 ₫
4.161.042 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Drury Plaza Hotel St. Louis at the Arch
Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
10.4 km from Downtown Clayton
9.4 out of 10, Exceptional, (2745)
"The room was clean and staff were very friendly."
United States
Denise
The price is 2.372.316 ₫
2.792.790 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Pear Tree Inn St. Louis Airport
Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
16.4 km from Downtown Clayton
8.0 out of 10, Very good, (1036)
"Everything was clean and friendly staff overall good experience "
United States
dennis
The price is 2.240.770 ₫
2.588.221 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Lobby
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis, 13.2 km from Downtown Clayton
8.4 out of 10, Very good, (4000)
"Arch view room is big and comfortable fantastic. . "
United States
Tim
The price is 2.348.854 ₫
2.769.980 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Hyatt Regency St. Louis at The Arch
Indoor pool
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station
3.0 star property
Downtown West, 11.3 km from Downtown Clayton
9.4 out of 10, Exceptional, (1297)
"Great location and staff are friendly. "
United States
GARY
The price is 3.136.814 ₫
3.730.486 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Drury Inn & Suites St. Louis Union Station
Ballroom
The Wildwood Hotel

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
26.5 km from Downtown Clayton
9.2 out of 10, Wonderful, (1598)
"Great place!"
United States
Biju
The Wildwood Hotel
Exterior
Moonrise Hotel

Moonrise Hotel

Moonrise Hotel
4.0 star property
3.4 km from Downtown Clayton
9.0 out of 10, Wonderful, (1912)
"Great service, unique hotel. Would absolutely stay again!"
United States
Michael
The price is 3.168.976 ₫
3.768.975 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Moonrise Hotel
Exterior
Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis, 12.9 km from Downtown Clayton
8.8 out of 10, Excellent, (1241)
"Great hospitality"
United States
Alejandro
The price is 2.826.006 ₫
3.360.941 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Embassy Suites by Hilton St. Louis Downtown
Room, 2 Queen Beds, Accessible, Non Smoking (Mobility, Tub W/Grab Bars) | Desk, laptop workspace, iron/ironing board, free cots/infant beds
Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport
2.5 star property
10.4 km from Downtown Clayton
9.2 out of 10, Wonderful, (1496)
"We enjoyed staying is very close to airport "
United States
Ellis
The price is 2.845.778 ₫
3.350.610 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Wingate by Wyndham St. Louis Airport
Interior
21C Museum Hotel St Louis

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West, 11.8 km from Downtown Clayton
9.0 out of 10, Wonderful, (1489)
"Room was perfect and parking was a breeze. We really enjoyed the art was wonderful. "
United States
London
The price is 3.338.747 ₫
4.035.773 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
21C Museum Hotel St Louis
Breakfast, lunch and dinner served
Live by Loews - St.Louis

Live by Loews - St.Louis

Live by Loews - St.Louis
4.0 star property
Downtown St. Louis, 12.7 km from Downtown Clayton
9.4 out of 10, Exceptional, (1101)
"Great staff"
United States
Phillip
The price is 3.927.938 ₫
4.671.457 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Live by Loews - St.Louis
Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis, 12.8 km from Downtown Clayton
8.8 out of 10, Excellent, (1147)
"So pleased with my stay would definitely recommend! Affordable and exclusive, staff ensured my stay was immaculate!"
United States
Meli
The price is 2.451.666 ₫
2.915.742 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Lobby
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown
3.0 star property
Downtown West, 12.2 km from Downtown Clayton
8.0 out of 10, Very good, (594)
"A convenient location downtown with great rooms and services."
United States
Paul
The price is 2.003.512 ₫
2.342.687 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Home2 Suites by Hilton St. Louis Downtown
Room, 2 Queen Beds | Hypo-allergenic bedding, free WiFi, bed sheets
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown
2.5 star property
Downtown West, 12.2 km from Downtown Clayton
7.6 out of 10, Good, (580)
"Everything great….very nice staff and security….delicious breakfast!!"
Canada
Derek
The price is 2.140.717 ₫
2.503.119 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Tru By Hilton St. Louis Downtown
Lobby
AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield
3.5 star property
20.3 km from Downtown Clayton
9.2 out of 10, Wonderful, (237)
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is 3.137.078 ₫
3.638.633 ₫ total
includes taxes & fees
21 Dec - 22 Dec
AC Hotel by Marriott St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown Clayton

Find the best Downtown Clayton areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Central West End

Central West End

If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Top Downtown Clayton Hotel Reviews

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Frequently asked questions

What's it like in Downtown Clayton?
Travellers to the Downtown Clayton neighbourhood in St. Louis will be sure to enjoy their stay.
How many hotels can I expect to find in the Downtown Clayton area?
Expedia has 5 Downtown Clayton hotels and other accommodation options, and one might make a good home base for venturing out into the greater St. Louis area.
If I need to cancel my hotel reservation in Downtown Clayton, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the top deals on offer in Downtown Clayton.
What can I see and do in this St. Louis neighbourhood?
Shaw Park Tennis Center, Saint Louis Galleria Mall and Tao Tennis Center are just a few of the places to visit in and around Downtown Clayton. While you're out sightseeing, Center of Creative Arts and Chapel of St. Timothy And St. Titus, Concordia Seminary are a couple of additional sights to visit in St. Louis.
How can I get around Downtown Clayton and the greater St. Louis area?
Ready to get out and explore the city? Clayton Station is the closest metro station.