Downtown South San Francisco Travel Guide

San Francisco

Aerial View of a Local High School and an Athletic Field in a Neighborhood in South San Francisco, California, USA
Aerial view of the South San Francisco area
Aerial view of downtown San Francisco and Financial District sky scrapers flying over South San Francisco The Industrial City inscription on San Bruno mountain circa 2015

Popular places to visit


Top hotels in Downtown South San Francisco

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3 out of 5
20 Airport Blvd South San Francisco CA
The price is 2.557.235 ₫ per night from 31 May to 1 Jun
2.557.235 ₫
3.006.777 ₫ total
31 May - 1 Jun
includes taxes & fees
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free Wi-Fi and a free airport shuttle. Our guests praise the breakfast and ...
8.2/10 Very Good! (1,976 reviews)
It was a very enjoyable stay. Very clean, breakfast was okay had a selection of basic foods. We didn't need parking however it looked as if there was plenty of space. The staff was Super friendly, helpful and went above what was expected. Thank You All!

Reviewed on 8 May 2026

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is 3.815.090 ₫ per night from 25 May to 26 May
3.815.090 ₫
5.574.101 ₫ total
25 May - 26 May
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the ...
9/10 Wonderful! (7,490 reviews)
The hotel was near pier 39 for easy walking. The breakfast buffet was well organized especially for being busy The front staff was awesome, well trained to explain your bill The only thing I was disappointed with was the parking price was not on the website It was reasonable for the city but I would ...

Reviewed on 10 May 2026

Hotel Riu Plaza Fisherman's Wharf
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is 3.466.211 ₫ per night from 25 May to 26 May
3.466.211 ₫
4.079.557 ₫ total
25 May - 26 May
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the pool and the ...
9/10 Wonderful! (5,724 reviews)
The property is accessible to tourists area. The parking is securedWe Love it!

Reviewed on 10 May 2026

Holiday Inn Golden Gateway by IHG
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is 3.197.070 ₫ per night from 25 May to 26 May
3.197.070 ₫
3.762.792 ₫ total
25 May - 26 May
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
8.8/10 Excellent! (2,740 reviews)
I will definitely stay here again

Reviewed on 10 May 2026

Hilton San Francisco Financial District
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
The price is 3.332.035 ₫ per night from 28 May to 29 May
3.332.035 ₫
3.921.620 ₫ total
28 May - 29 May
includes taxes & fees
Stay at this business-friendly hotel in San Francisco. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the ...
9/10 Wonderful! (3,137 reviews)
Location was close to everything However parking was extremely high We paid $45 per day .. they provide coffee in the room and also downstairs Otherwise hotel was great

Reviewed on 10 May 2026

Club Quarters Hotel in San Francisco
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
The price is 4.188.393 ₫ per night from 24 May to 25 May
4.188.393 ₫
4.929.518 ₫ total
24 May - 25 May
includes taxes & fees
Stay at this family-friendly hotel in San Francisco. Enjoy free Wi-Fi, a fitness centre and valet parking (surcharge). Our guests praise the pool and the helpful ...
8.8/10 Excellent! (3,116 reviews)
Ac didn't work in our room and when we showered we realized the shampoo & conditioner were completely empty and had to call the front desk to refill them. Also didn't read that you have to pay for the valet parking which was almost half of what the room cost.

Reviewed on 10 May 2026

Handlery Union Square Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Downtown South San Francisco

Aerial View Of Urban Neighborhood

Noe Valley

Appreciated for its churches and architecture, you might consider exploring Noe Valley. Check out the variety of things to see and do like 22nd St Hill, and jump on the metro at Church St & Clipper St Stop or Church St & 24th St Stop to get around the city.

Noe Valley
Mission District

Mission District

3.5/5(11 area reviews)

You might enjoy the bars while in Mission District. San Francisco Public Library is a notable sight, and you can get around town at 16th Street Mission Station or 24th Street Mission Station to see more of the city.

Mission District
Potrero Hill

Potrero Hill

The live music and architecture are just a few things visitors like about Potrero Hill. San Francisco Bay and Museum of Craft & Design are worthwhile spots to check out, and you can hop on the metro at 20th Street Station or 23rd Street Station to get around the larger area.

Potrero Hill
Sunset District

Sunset District

3.5/5(6 area reviews)

Consider exploring the beaches in Sunset District. If sightseeing is on the list, Ocean Beach is a top attraction. Hop on the metro at Judah Street & Sunset Boulevard Station or Judah St & 34th Ave Stop to see more of the area.

Sunset District
South of Market

South of Market

3.5/5(115 area reviews)

Gourmet restaurants great entertainment and top sights from Oracle Park to San Francisco Bay – discover South of Market, a destination also famous for its shopping.

South of Market
Ariel view of the California Academy of Sciences in San Francisco, California.

Golden Gate

If you're spending time in Golden Gate, check out sights like San Francisco Botanical Garden or Japanese Tea Garden and hop on the metro to see more of the city at Irving St & 9th Ave Stop or Irving St & 8th Ave Stop.

Golden Gate


Downtown South San Francisco Travel Guide

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