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Search Casino Hotels in Cape Girardeau

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Check availability on Cape Girardeau Casino Hotels

Our top choices for Cape Girardeau hotels with a casino

Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (469)
"Place was nice and safe"
United States
ryan
The price is 2.538.179 ₫
2.863.421 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The Riverview
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is 3.057.412 ₫
3.464.477 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Cape Girardeau Downtown
Lobby
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is 3.956.722 ₫
4.463.555 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Rockwood Inn
Exterior
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (663)
"Great place "
United States
GUY
The price is 2.217.942 ₫
2.400.368 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

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Frequently asked questions

Searching for casino hotels in Cape Girardeau?
Hoping to win big in Cape Girardeau? As luck would have it, you'll find Isle Casino Cape Girardeau here, plus much more to see and do. Visitors enjoy the riverfront, shopping and dining options.
How many hotels that are good for gaming will I find in Cape Girardeau?
Practise your poker face at one of Expedia's 57 hotels in Cape Girardeau.
When should I take my casino trip to Cape Girardeau?
You might spend a lot of your holiday inside, but if you're planning to venture beyond the casino, taking a look at local weather data can help you. The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cape Girardeau is 1495 mm.
What is there to do in Cape Girardeau?
Cape Girardeau is known for its historic sites, offering you opportunities to enjoy the local culture. Some attractions to visit in the area are Cape Girardeau Conservation Nature Center and Lazy L Safari Park. For more to see and do, you can plan to visit Show Me Center and Cape Splash Family Aquatic Center.
What are my transportation options for my casino getaway to Cape Girardeau?
Getting around Cape Girardeau is easier with these transportation options: Fly into the closest airport, which is Cape Girardeau, MO (CGI-Cape Girardeau Municipal), 6 mi (9.7 km) from the city centre. If you'd like to venture out around the area, consider renting a car to explore more sights.