South Main Travel Guide
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the great live music and acclaimed art galleries in this vibrant area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and acclaimed theatre scene in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the entertainment choices and acclaimed art galleries in this vibrant area.
Space Center Houston
Explore the exhibits at Space Center Houston, a favourite museum in Houston. Amble around the area's lakeside or attend a sporting event.
Top hotels in South Main
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The customer service of Michael. Very polite and courteous.
Reviewed on 28 Feb 2026
Hotel Zaza Houston Museum District
Fantastic all around
Reviewed on 27 Feb 2026
Blossom Hotel Houston, Curio Collection by Hilton
Everything was awesome
Reviewed on 28 Feb 2026
The Royal Sonesta Houston Galleria
Great room
Reviewed on 28 Feb 2026
The Whitehall Houston
We stayed here after our cruise and had a great experience overall. The room was spacious, the bed was very comfortable, and everything felt well maintained. We were especially impressed by the restaurant, both the food and atmosphere were excellent. Shirley, John, and the restaurant team were incredibly ...
Reviewed on 28 Feb 2026
Club Quarters Hotel Downtown, Houston
Good location, very fit for purpose. Room was
Reviewed on 28 Feb 2026
Other neighbourhoods around South Main
Astrodome
While you're in Astrodome, take in top sights like NRG Stadium or NRG Astrodome, and hop on the metro to see more of the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
Greenway Plaza-Upper Kirby
Greenway Plaza-Upper Kirby is known for its abundant dining options, and you can plan a trip to Highland Village and Richmond Avenue while you're in town.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
