Photo by Linda Cronan

Compare and book 4 Star hotels in Medical Center District, San Antonio

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check availability on Medical Center District 4 Star Hotels

Tonight
4 Jul - 5 Jul
Tomorrow
5 Jul - 6 Jul
This weekend
4 Jul - 6 Jul
Next weekend
11 Jul - 13 Jul

Top Medical Center District 4 Star Hotels

Riverwalk Plaza
Games room

Riverwalk Plaza

4.0 star property
8.2 out of 10, Very good, (5458)
"Great place to stay with family. "
The price is 2.282.896 ₫
2.698.588 ₫ total
includes taxes & fees
28 Jul - 29 Jul
Riverwalk Plaza
La Cantera Resort & Spa
Private pool

La Cantera Resort & Spa

4.0 star property
9.0 out of 10, Wonderful, (1009)
"This is an absolutely beautiful resort. I definitely will stay here again when I am in San Antonio."
The price is 6.029.254 ₫
8.590.700 ₫ total
includes taxes & fees
6 Jul - 7 Jul
La Cantera Resort & Spa
Hyatt Regency Hill Country Resort & Spa
3 outdoor pools, pool cabanas (surcharge), pool loungers

Hyatt Regency Hill Country Resort & Spa

4.0 star property
8.8 out of 10, Excellent, (1004)
"Love this resort. We have tried others in the area, but this one seems to be the best for our family. "
The price is 6.283.200 ₫
9.019.243 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Hyatt Regency Hill Country Resort & Spa
Hotel Contessa
Outdoor pool, a heated pool, open 8:00 AM to 10:00 PM, free pool cabanas

Hotel Contessa

4.0 star property
9.0 out of 10, Wonderful, (3101)
"Great stay for our family in the perfect location "
Hotel Contessa
Plaza San Antonio Hotel & Spa, Autograph Collection
Outdoor pool, open 9:00 AM to 10:00 PM, pool cabanas (surcharge)

Plaza San Antonio Hotel & Spa, Autograph Collection

4.0 star property
9.2 out of 10, Wonderful, (515)
"friendly staff overall and very nice amenities plus clean room "
The price is 3.760.757 ₫
5.238.454 ₫ total
includes taxes & fees
17 Jul - 18 Jul
Plaza San Antonio Hotel & Spa, Autograph Collection
Hyatt Regency San Antonio Riverwalk
View from property

Hyatt Regency San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (1786)
"Enjoyed the motel close to restaurants "
The price is 4.424.420 ₫
6.153.038 ₫ total
includes taxes & fees
1 Aug - 2 Aug
Hyatt Regency San Antonio Riverwalk
JW Marriott San Antonio Hill Country Resort & Spa
4 outdoor pools, pool cabanas (surcharge), pool umbrellas

JW Marriott San Antonio Hill Country Resort & Spa

4.5 star property
8.8 out of 10, Excellent, (1005)
"Great family resort"
The price is 8.613.220 ₫
11.892.200 ₫ total
includes taxes & fees
9 Jul - 10 Jul
JW Marriott San Antonio Hill Country Resort & Spa
Grand Hyatt San Antonio River Walk
Premium bedding, pillow-top beds, in-room safe, desk

Grand Hyatt San Antonio River Walk

4.0 star property
9.0 out of 10, Wonderful, (1188)
"Beautiful hotel, great location! "
The price is 4.427.969 ₫
6.079.240 ₫ total
includes taxes & fees
28 Jul - 29 Jul
Grand Hyatt San Antonio River Walk
Omni La Mansion del Rio
Outdoor pool

Omni La Mansion del Rio

4.0 star property
9.4 out of 10, Exceptional, (2641)
"beautiful hotel, friendly staff, great location."
The price is 4.701.404 ₫
5.640.845 ₫ total
includes taxes & fees
22 Jul - 23 Jul
Omni La Mansion del Rio
InterContinental San Antonio Riverwalk by IHG
2 restaurants, breakfast served

InterContinental San Antonio Riverwalk by IHG

4.5 star property
9.4 out of 10, Exceptional, (446)
"Wonderful place!!"
The price is 3.983.287 ₫
5.602.846 ₫ total
includes taxes & fees
13 Jul - 14 Jul
InterContinental San Antonio Riverwalk by IHG
Hotel Valencia Riverwalk
Terrace/patio

Hotel Valencia Riverwalk

4.5 star property
9.4 out of 10, Exceptional, (1922)
"Such a nice hotel and accommodations!"
The price is 3.542.375 ₫
4.868.407 ₫ total
includes taxes & fees
9 Jul - 10 Jul
Hotel Valencia Riverwalk
The Westin San Antonio North
Indoor pool, outdoor pool

The Westin San Antonio North

4.0 star property
8.6 out of 10, Excellent, (1003)
"Nice safe place to spend the night while traveling through Texas. "
The price is 2.114.035 ₫
2.537.463 ₫ total
includes taxes & fees
3 Aug - 4 Aug
The Westin San Antonio North
The Westin Riverwalk, San Antonio
Breakfast, lunch, dinner served; Italian cuisine

The Westin Riverwalk, San Antonio

4.0 star property
8.8 out of 10, Excellent, (1235)
"Excellent Hotel in great location "
The price is 4.137.662 ₫
4.927.770 ₫ total
includes taxes & fees
27 Jul - 28 Jul
The Westin Riverwalk, San Antonio
Element San Antonio Riverwalk
Bar (on property)

Element San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (865)
"Great place to stay smells amazing as well"
The price is 2.905.980 ₫
3.435.129 ₫ total
includes taxes & fees
27 Jul - 28 Jul
Element San Antonio Riverwalk
Canopy by Hilton San Antonio Riverwalk
Terrace/patio

Canopy by Hilton San Antonio Riverwalk

4.0 star property
9.2 out of 10, Wonderful, (1494)
"Great hotel for a quick weekend trip "
The price is 3.542.375 ₫
4.894.833 ₫ total
includes taxes & fees
28 Jul - 29 Jul
Canopy by Hilton San Antonio Riverwalk
Hilton San Antonio Hill Country
Exterior

Hilton San Antonio Hill Country

4.0 star property
8.4 out of 10, Very good, (1002)
"This hotel is the perfect place to stay while visiting San Antonio. The staff is great, the environment is fantastic, and there are plenty of fun activities to enjoy. "
The price is 3.315.697 ₫
4.969.008 ₫ total
includes taxes & fees
13 Jul - 14 Jul
Hilton San Antonio Hill Country
AC Hotel by Marriott San Antonio Riverwalk
View from property

AC Hotel by Marriott San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (801)
"Property was nice along with the room and surrounding riverwalk area. I would stay here again. "
The price is 3.120.656 ₫
3.688.762 ₫ total
includes taxes & fees
6 Jul - 7 Jul
AC Hotel by Marriott San Antonio Riverwalk
The St. Anthony, A Luxury Collection Hotel, San Antonio
Meeting facility

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 star property
8.8 out of 10, Excellent, (1000)
"Great location and service. Beautiful hotel"
The price is 4.300.065 ₫
5.083.064 ₫ total
includes taxes & fees
3 Aug - 4 Aug
The St. Anthony, A Luxury Collection Hotel, San Antonio
Kimpton Santo San Antonio - Riverwalk by IHG
Outdoor pool

Kimpton Santo San Antonio - Riverwalk by IHG

4.5 star property
9.2 out of 10, Wonderful, (336)
"Was a excellent place to stay"
The price is 4.072.299 ₫
5.489.684 ₫ total
includes taxes & fees
31 Jul - 1 Aug
Kimpton Santo San Antonio - Riverwalk by IHG
Hilton Palacio Del Rio
Exterior

Hilton Palacio Del Rio

4.0 star property
8.8 out of 10, Excellent, (1004)
"Hotel and staff were excellent"
The price is 4.205.817 ₫
4.971.653 ₫ total
includes taxes & fees
28 Jul - 29 Jul
Hilton Palacio Del Rio
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District.
Thompson San Antonio - Riverwalk, by Hyatt

Thompson San Antonio - Riverwalk, by Hyatt

115 Lexington Avenue, San Antonio, TX
The price is 5.540.997 ₫ per night from 13 Jul to 14 Jul
5.540.997 ₫
7.442.296 ₫ total
13 Jul - 14 Jul
includes taxes & fees
9/10 Wonderful! (771 reviews)
Still don't see what you're looking for?
See all properties in Medical Center District.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the best 4-star hotels in Medical Centre District?
Put your suitcase down and relax into your holiday at The Westin San Antonio North. This 4-star hotel is one of Expedia's travellers' top picks around Medical Centre District.
How much does it cost to stay in a 4-star hotel in Medical Centre District?
We can help you quickly find the ideal 4-star hotel for your trip to Medical Centre District. Use our handy filter tool to tailor your search by things like budget, amenities and star rating and get access to fabulous deals in a few clicks.

  • Search for the lowest price from 5.540.997 ₫

What's the difference between 5-star and 4-star hotels in Medical Centre District?
Give yourself the luxury treatment during your Medical Centre District escape by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities such as large beds, complimentary bathrobes and more. A 5-star hotel will go the extra mile to make your trip an even more lavish and unforgettable one. Concierge assistance, elegant furnishings and world-class dining are a few of the first-rate conveniences and services you'll likely have access to.