Medical Center District Travel Guide

San Antonio

Photo by Linda Cronan

Popular places to visit


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is 2.332.954 ₫ per night from 19 Jan to 20 Jan
2.332.954 ₫
2.757.510 ₫ total
19 Jan - 20 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,174 reviews)
Great area and breakfast.

Reviewed on 17 Jan 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is 2.657.413 ₫ per night from 23 Jan to 24 Jan
2.657.413 ₫
3.157.852 ₫ total
23 Jan - 24 Jan
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,000 reviews)
Nice stay

Reviewed on 13 Jan 2026

San Antonio Marriott Northwest Medical Center
Park Inn by Radisson

Park Inn by Radisson

2 out of 5
7500 Louis Pasteur Drive San Antonio TX
The price is 1.652.509 ₫ per night from 31 Jan to 1 Feb
1.652.509 ₫
1.929.304 ₫ total
31 Jan - 1 Feb
includes taxes & fees
Stay at this motel in San Antonio. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff in their reviews. Popular attractions ...
7.2/10 Good! (1,000 reviews)
Friendly staff Clean room

Reviewed on 14 Jan 2026

Park Inn by Radisson
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is 2.459.322 ₫ per night from 25 Jan to 26 Jan
2.459.322 ₫
3.657.851 ₫ total
25 Jan - 26 Jan
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (2,389 reviews)
Beautiful hotel! Loved everything about our stay. Service, decor, bar….all of it! We will definitely be back!

Reviewed on 18 Jan 2026

Hotel Valencia Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the ...
8/10 Very Good! (6,316 reviews)
Great stay. Older hotel but service was good. Hotel was clean.

Reviewed on 12 Jan 2026

Riverwalk Plaza
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
The price is 3.257.728 ₫ per night from 24 Jan to 25 Jan
3.257.728 ₫
3.850.928 ₫ total
24 Jan - 25 Jan
includes taxes & fees
Stay at this historic hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the pool and the bar in their reviews. ...
8.8/10 Excellent! (3,682 reviews)
Our stay at the Menger Hotel was truly lovely! The adornment throughout is beautiful, the service prompt and thorough, and the easy access to the riverwalk and surrounding area was very convenient! We especially loved the servers at breakfast, so personable and kind. I recommend this place 100%!

Reviewed on 12 Jan 2026

Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

Northwest Side
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio River or The DoSeum while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

Tobin Hill might not have many top sights, but San Antonio River and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
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Uptown

If you're spending some time in Uptown, San Antonio River and Marion Koogler McNay Art Museum are top sights worth seeing.

Uptown
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Alamo Heights

You'll enjoy the museums and coffee shops in Alamo Heights. You might want to make time for a stop at San Antonio River or Harry B Orem Stadium.

Alamo Heights


Medical Center District Travel Guide

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