Search Business Hotels in Central San Diego

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Check availability on Central San Diego Business Hotels

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Top Central San Diego Business Hotels

Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

2.5 star property
Mission Valley
8.8 out of 10, Excellent, (1269)
"Spacious and clean rooms, helpful staff"
United States
Gholam
The price is 2.636.300 ₫
3.030.295 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn San Diego/Mission Valley
Outdoor pool, pool umbrellas, pool loungers
Handlery Hotel

Handlery Hotel

3.5 star property
Mission Valley
8.2 out of 10, Very good, (2209)
"Staff was amazing and very accommodating. Always recommended staying here. "
United States
Taja
Handlery Hotel
Exterior
Courtyard by Marriott Old Town

Courtyard by Marriott Old Town

3.0 star property
Old Town San Diego
8.6 out of 10, Excellent, (1003)
"Nice staying there "
United States
Jennifer
The price is 3.142.470 ₫
3.612.113 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Courtyard by Marriott Old Town
Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)
Lafayette Hotel & Club

Lafayette Hotel & Club

4.0 star property
University Heights
9.4 out of 10, Exceptional, (1313)
"Loved everything, I could stay there forever"
United States
Mariana
The price is 5.958.038 ₫
6.836.849 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Lafayette Hotel & Club
Daily buffet breakfast for a fee
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4.0 star property
Mission Valley
8.4 out of 10, Very good, (1385)
"Great hotel in a great area - would definitely stay here again."
United States
Bhupinder
The price is 3.004.855 ₫
3.453.931 ₫ total
includes taxes & fees
14 Dec - 15 Dec
DoubleTree by Hilton Hotel San Diego - Mission Valley
Outdoor pool, pool loungers
Hyatt Regency La Jolla

Hyatt Regency La Jolla

4.0 star property
University City
8.8 out of 10, Excellent, (1004)
"Clean rooms, excellent staff and Drift restaurant is also very nice "
United States
Paresh
The price is 3.787.045 ₫
5.327.656 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hyatt Regency La Jolla
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2948)
"Friendly, staff was very helpful, great size rooms, and over all was an amazing stay"
United States
Naya
The price is 4.011.130 ₫
4.610.593 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Legacy Resort Hotel & Spa
Outdoor pool, a heated pool
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3.0 star property
Mission Valley
8.0 out of 10, Very good, (2425)
"Front desk staff was kind, knowledgeable and efficient "
United States
Elizabeth
The price is 2.330.489 ₫
2.678.781 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Days Inn by Wyndham San Diego Hotel Circle
Outdoor pool, pool loungers
Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town

3.0 star property
Old Town San Diego
8.4 out of 10, Very good, (1850)
"Excellent location, courteous staff, great airport shuttle, delicious on-site restaurant."
United States
Kathleen
The price is 3.061.008 ₫
3.518.475 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Best Western Plus Hacienda Hotel Old Town
BBQ/picnic Area
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 star property
Mission Hills
9.2 out of 10, Wonderful, (1028)
"Clean room, amenities, quiet. "
United States
Casandra
The price is 3.585.368 ₫
4.121.201 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

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Frequently asked questions

Why book your business-friendly hotel in Central San Diego with Expedia?
Expedia will help you find the ideal business-friendly hotel for your upcoming work trip. From meeting rooms and conference spaces to on-site restaurants and more, our accommodation have all you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Central San Diego?
Click on the "business friendly" filter, located under the "traveller experience" heading, to find cheap business-friendly hotels in Central San Diego. Then fine-tune your search by your nightly budget. Looking for properties away from the centre can also help you save.