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Check availability on La Mesa Luxury Hotels

Our top choices for La Mesa luxury hotels

3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1634)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
Exterior
Viejas Casino & Willows Hotel

Viejas Casino & Willows Hotel

4.0 star property
Alpine
9.2 out of 10, Wonderful, (1002)
"Nice location and the ambient was the best."
United States
ivan
The price is 3.250.962 ₫
4.052.894 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Viejas Casino & Willows Hotel
Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)
Lafayette Hotel & Club

Lafayette Hotel & Club

4.0 star property
University Heights
9.4 out of 10, Exceptional, (1320)
"My wife loved everything about this vintage hotel."
United States
Eddie
The price is 5.957.812 ₫
6.836.721 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Lafayette Hotel & Club
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1855)
"Enjoyed my stay"
United States
Brandon
The price is 2.174.865 ₫
3.815.999 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Hilton San Diego Bayfront
Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4.0 star property
Mission Bay
8.4 out of 10, Very good, (1568)
"Loved our stay "
United States
Jeremy
The price is 3.060.628 ₫
4.912.852 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Hyatt Regency Mission Bay Spa and Marina
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4.0 star property
Mission Bay
8.4 out of 10, Very good, (1308)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is 4.191.558 ₫
6.006.318 ₫ total
includes taxes & fees
14 Dec - 15 Dec
San Diego Mission Bay Resort
Exterior
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4.0 star property
Silver Strand
8.8 out of 10, Excellent, (1068)
"My stay was wonderful! "
United States
Jeanine
The price is 4.718.798 ₫
6.517.740 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Loews Coronado Bay Resort
Breakfast, lunch, dinner served; sea views
Hotel La Jolla, Curio Collection by Hilton

Hotel La Jolla, Curio Collection by Hilton

4.0 star property
La Jolla Shores
8.4 out of 10, Very good, (467)
"Loved the decor, the staff, size of rooms and the Sea and Sky restaurant is ourstanding."
United States
Becky
The price is 4.112.472 ₫
5.619.171 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Hotel La Jolla, Curio Collection by Hilton
Terrace/patio
The Bower Coronado

The Bower Coronado

5.0 star property
Historic Downtown Coronado
9.2 out of 10, Wonderful, (149)
"Right near the beach and an overall positive experience! "
United States
Zachary
The price is 5.433.208 ₫
7.294.629 ₫ total
includes taxes & fees
11 Dec - 12 Dec
The Bower Coronado
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (80)
"It was a nice place to stay at"
United States
Eric
The price is 2.899.820 ₫
3.362.196 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Courtyard by Marriott San Diego Downtown Little Italy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top La Mesa Hotel Reviews

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent
"The room was pretty great there was a nice view of the town, but we could see homeless people in tents sleeping, so there was that. Front desk was amazing. The bar downstairs was great my husband went down and had a drink and watched some sports. Overall a great trip: for a three-star hotel, it was fantastic! Price of room was average, but the parking was a little much at $37.50 for one 24 hour peri[parking fr 9:00 p.m. to 5:00 a.m. was steep."
Jennifer 1-night trip
Posted 3 days ago
The DEXTRO Little Italy, BW Premier Collection
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Hotel was great, no regrets at all."
Gabriel 2-night trip
Posted 4 days ago
Courtyard by Marriott San Diego Downtown Little Italy

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Frequently asked questions

Are you searching for a great accommodation for your luxury getaway to La Mesa?
Use Expedia and let us help you arrange a flight to San Diego, CA (SEE-Gillespie Field) airport or San Diego, CA (MYF-Montgomery Field) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to get what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with fine dining, a spa or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that La Mesa has to offer. During your visit, you might want to enjoy the entertainment which La Mesa is known for.
When can I expect good weather in La Mesa?
Planning for the weather is an important factor for making your trip to La Mesa a success, especially when you're splurging. The hottest months are usually August and September, with an average temperature of 22°C, while the coldest months are February and January, with an average of 14°C. Average annual precipitation for La Mesa is 308 mm.
What's there to see and do in La Mesa?
Enjoy La Mesa with a stop at Mount Helix Park, San Diego Zoo and Petco Park. If you have a bit of extra time while you're in the area, you might want to check out Port of San Diego and Mission Bay.
How can I get around La Mesa?
It's easier to get around town in style when you know your options. Nearby metro stations include La Mesa Boulevard Station, Spring St Trolley Station and 70th St. Trolley Station.