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Check availability on Otay Mesa Family-Friendly Hotels

Our top choices for Otay Mesa family-friendly hotels

Desk, laptop workspace, blackout curtains, iron/ironing board
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1005)
"Beautiful place "
United States
Joe
The price is 2.609.838 ₫
2.968.691 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Quality Suites San Diego Otay Mesa
Outdoor pool
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
7.8 out of 10, Good, (1010)
"Good value Nice place to stay "
United States
John
The price is 2.241.450 ₫
2.587.621 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Crowne Plaza San Diego - Mission Valley by IHG
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1855)
"Enjoyed my stay"
United States
Brandon
The price is 2.294.190 ₫
3.954.511 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Hilton San Diego Bayfront
3 outdoor pools, open 7:00 AM to 10:00 PM, pool umbrellas, pool loungers
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.2 out of 10, Very good, (3172)
"Great stay! "
United States
Melissa
The price is 2.478.780 ₫
3.798.554 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Sheraton San Diego Resort
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1308)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is 3.102.694 ₫
4.755.039 ₫ total
includes taxes & fees
14 Dec - 15 Dec
San Diego Mission Bay Resort
Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1568)
"Loved our stay "
United States
Jeremy
The price is 3.061.557 ₫
4.914.344 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Hyatt Regency Mission Bay Spa and Marina
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (725)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is 2.577.892 ₫
2.988.937 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The DEXTRO Little Italy, BW Premier Collection
Reception
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
Point Loma
8.8 out of 10, Excellent, (1553)
"Clean room, happy, helpful staff, great resturant. It was the week we needed to get away."
United States
GERALD
The price is 2.995.632 ₫
3.443.330 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Best Western Plus Island Palms Hotel & Marina
2 restaurants, dinner served, American cuisine
Kings Inn San Diego

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (3561)
"Room was very clean, and the breakfast was good"
United States
Roxana
The price is 1.973.591 ₫
2.264.695 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Kings Inn San Diego
Private beach, beach cabanas, sun-loungers, beach umbrellas
Kona Kai San Diego

Kona Kai San Diego

Kona Kai San Diego
4.0 star property
Point Loma
8.2 out of 10, Very good, (1000)
"had a wonderful time for our honey moon here "
United States
Anna
The price is 3.968.441 ₫
6.143.245 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Kona Kai San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Leigh at the front desk."
Randolph 1-night trip
Posted 1 day ago
Hampton Inn & Suites by Hilton San Diego SeaWorld

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Frequently asked questions

What's Otay Mesa like for family-friendly holidays?
If you've been thinking about a trip with your children, the culturally rich destination of Otay Mesa is a good choice. The beaches, sporting events and restaurants are just some of the things that make this an attractive spot for a family holiday. Take to the air and fly into Tijuana, Baja California Norte (TIJ-General Abelardo L. Rodriguez Intl.), which is the closest airport, or San Diego, CA (SAN-San Diego Intl.), which is located 17.7 mi (28.4 km) from the centre of Otay Mesa.
What's there to see and do with your family in Otay Mesa?
Petco Park and High Performance Center in Tijuana are interesting attractions that you and your family may enjoy exploring while you are staying in Otay Mesa. Make sure that you have plenty of time to take in activities in the area such as San Diego Zoo, San Ysidro Border Crossing and Port of San Diego.