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Check availability on Otay Mesa Hotels with Air Conditioning

Our top choices for Otay Mesa hotels with air conditioning

Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1557)
"Good comfortable beds good breakfast "
United States
Andrey
The price is 3.133.151 ₫
3.563.959 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Free on-the-go breakfast
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1000)
"Beautiful place "
United States
Joe
The price is 2.768.494 ₫
3.149.162 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Quality Suites San Diego Otay Mesa
Property amenity
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
7.8 out of 10, Good, (1001)
"Good value Nice place to stay "
United States
John
The price is 2.327.484 ₫
2.686.322 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Crowne Plaza San Diego - Mission Valley by IHG
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1857)
"Enjoyed my stay"
United States
Brandon
The price is 2.685.558 ₫
4.405.501 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Hilton San Diego Bayfront
Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.2 out of 10, Very good, (3176)
"Great stay! "
United States
Melissa
The price is 2.474.926 ₫
3.792.648 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Sheraton San Diego Resort
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1630)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1309)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is 3.097.870 ₫
4.747.758 ₫ total
includes taxes & fees
14 Dec - 15 Dec
San Diego Mission Bay Resort
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (727)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is 2.573.883 ₫
2.984.290 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The DEXTRO Little Italy, BW Premier Collection
Exterior
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
Mission Valley
8.8 out of 10, Excellent, (1278)
"Room was clean,buffet bkfast was good,staff were friendly & helpful!"
United States
Barry
The price is 2.506.521 ₫
2.881.121 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn San Diego/Mission Valley
Exterior
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
Point Loma
8.8 out of 10, Excellent, (1554)
"Every time i have stayed here everything is always clean...no complaints!"
United States
Joseline
The price is 3.012.038 ₫
3.462.187 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Island Palms Hotel & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa Hotel Reviews

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Excellent, perfect location, modern and upgraded"
Robert 1-night trip
Posted 18 hours ago
Courtyard by Marriott San Diego Downtown Little Italy

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