Search Hotels with Air Conditioning in Otay Mesa
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check availability on Otay Mesa Hotels with Air Conditioning
Our top choices for Otay Mesa hotels with air conditioning

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very good, (1557)
The price is 3.133.151 ₫
3.563.959 ₫ total
includes taxes & fees
14 Dec - 15 Dec

7.2 out of 10, Good, (1000)
The price is 2.768.494 ₫
3.149.162 ₫ total
includes taxes & fees
14 Dec - 15 Dec

Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHGMission Valley
7.8 out of 10, Good, (1001)
The price is 2.327.484 ₫
2.686.322 ₫ total
includes taxes & fees
14 Dec - 15 Dec

8.6 out of 10, Excellent, (1857)
The price is 2.685.558 ₫
4.405.501 ₫ total
includes taxes & fees
20 Dec - 21 Dec

8.2 out of 10, Very good, (3176)
The price is 2.474.926 ₫
3.792.648 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026

9.2 out of 10, Wonderful, (1630)

8.4 out of 10, Very good, (1309)
The price is 3.097.870 ₫
4.747.758 ₫ total
includes taxes & fees
14 Dec - 15 Dec

The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier CollectionDowntown San Diego
8.8 out of 10, Excellent, (727)
The price is 2.573.883 ₫
2.984.290 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Otay Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld
10/10 Excellent
Explore a world of travel with Expedia
Choose Your Otay Mesa Hotel Style
- Beach Resorts & Hotels in Otay Mesa
- Business Hotels in Otay Mesa
- Casino Hotels in Otay Mesa
- Cheap Hotels in Otay Mesa
- Family-Friendly Hotels in Otay Mesa
- Golf Hotels in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels Suites in Otay Mesa
- Hotels near Museums in Otay Mesa
- Hotels with Breakfast in Otay Mesa
- Hotels with Connecting Rooms in Otay Mesa
- Hotels with Entertainment in Otay Mesa
- Hotels with Gym in Otay Mesa
- Hotels with Laundry Service in Otay Mesa
- Hotels with Parking in Otay Mesa
- Hotels with Wifi in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Shopping Hotels in Otay Mesa
- Spa Hotels in Otay Mesa


































