Search Business Hotels in Otay Mesa

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Otay Mesa Business Hotels

Our top choices for Otay Mesa business-friendly hotels

Desk, laptop workspace, blackout curtains, iron/ironing board
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2.5 star property
Otay Mesa
7.2 out of 10, Good, (1004)
"Beautiful place "
United States
Joe
The price is 2.609.838 ₫
2.968.691 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Quality Suites San Diego Otay Mesa
Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1553)
"Good comfortable beds good breakfast "
United States
Andrey
The price is 3.138.030 ₫
3.569.509 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Outdoor pool
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

3.5 star property
Mission Valley
7.8 out of 10, Good, (1009)
"Good value Nice place to stay "
United States
John
The price is 2.241.450 ₫
2.587.621 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Crowne Plaza San Diego - Mission Valley by IHG
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1634)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

4.0 star property
Harbor Island
8.2 out of 10, Very good, (3171)
"Great stay! "
United States
Melissa
The price is 2.478.028 ₫
3.797.401 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Sheraton San Diego Resort
Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4.0 star property
Mission Bay
8.4 out of 10, Very good, (1568)
"Loved our stay "
United States
Jeremy
The price is 3.060.628 ₫
4.912.852 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Hyatt Regency Mission Bay Spa and Marina
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (725)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is 2.577.892 ₫
2.988.937 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The DEXTRO Little Italy, BW Premier Collection
Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

2.5 star property
Mission Valley
8.8 out of 10, Excellent, (1277)
"Spacious and clean rooms, helpful staff"
United States
Gholam
The price is 2.551.842 ₫
2.933.215 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn San Diego/Mission Valley
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1855)
"Enjoyed my stay"
United States
Brandon
The price is 2.174.865 ₫
3.815.999 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Hilton San Diego Bayfront
Lobby
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

3.0 star property
Point Loma
7.4 out of 10, Good, (4108)
"Clean rooms and friendly staff."
United States
Aniket
The price is 2.228.907 ₫
2.562.017 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Wyndham Garden San Diego Near SeaWorld
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Otay Mesa Hotel Reviews

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent
"The room was pretty great there was a nice view of the town, but we could see homeless people in tents sleeping, so there was that. Front desk was amazing. The bar downstairs was great my husband went down and had a drink and watched some sports. Overall a great trip: for a three-star hotel, it was fantastic! Price of room was average, but the parking was a little much at $37.50 for one 24 hour peri[parking fr 9:00 p.m. to 5:00 a.m. was steep."
Jennifer 1-night trip
Posted 3 days ago
The DEXTRO Little Italy, BW Premier Collection

Explore a world of travel with Expedia

Frequently asked questions

Why book your business-friendly hotel in Otay Mesa with Expedia?
Here at Expedia, our business is to help you land an excellent stay at the right price. From upmarket, corporate-friendly retreats to affordable hotels loaded with amenities, you'll have your next work trip organised in a few quick clicks.
How can I find cheap business-friendly hotels in Otay Mesa?
Select the "business friendly" filter, listed under the "traveller experience" heading, to find cheap business-friendly hotels in Otay Mesa. Then refine your search by your nightly budget. Looking for properties outside the city centre is another good way to save.