Compare and book 4 Star hotels in Otay Mesa, San Diego

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Check availability on Otay Mesa 4 Star Hotels

Our top choices for Otay Mesa 4-star hotels

Lobby
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton
4.0 star property
Historic Downtown Coronado
8.4 out of 10, Very good, (1007)
"Beautiful rooms, great activities, wonderful staff "
United States
Kyle
The price is 8.943.385 ₫
11.392.802 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel del Coronado, Curio Collection by Hilton
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (3142)
"Great stay"
United States
Laurence
The price is 4.484.176 ₫
6.410.975 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hard Rock Hotel San Diego
Daily buffet breakfast for a fee
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley
4.0 star property
Mission Valley
8.4 out of 10, Very good, (1397)
"Great hotel in a great area - would definitely stay here again."
United States
Bhupinder
The price is 3.113.770 ₫
3.579.123 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (80)
"It was a nice place to stay at"
United States
Eric
The price is 2.899.820 ₫
3.362.197 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Courtyard by Marriott San Diego Downtown Little Italy
Lobby
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

Hilton San Diego Mission Valley
4.0 star property
Mission Valley
8.0 out of 10, Very good, (2239)
"Excelente hotel"
Mexico
Julio
The price is 3.114.670 ₫
3.580.157 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hilton San Diego Mission Valley
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2958)
"Everything was super comfortable and the room was surprisingly affordable for the amenities you get. We will definitely stay there again if we go to San Diego."
United States
Eric
The price is 4.012.195 ₫
4.611.818 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Legacy Resort Hotel & Spa
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
Downtown San Diego
8.4 out of 10, Very good, (6039)
"Always an amazing stay"
United States
Jana
The price is 3.563.906 ₫
4.896.902 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Wyndham San Diego Bayside
Lobby
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1541)
"Clean room, friendly staff, great property. "
United States
MIGUEL
The price is 4.303.584 ₫
5.946.495 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Embassy Suites by Hilton San Diego Bay Downtown
Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)
Lafayette Hotel & Club

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (1321)
"My wife loved everything about this vintage hotel."
United States
Eddie
The price is 5.957.812 ₫
6.836.589 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Lafayette Hotel & Club
Outdoor pool
Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel
4.0 star property
Mission Valley
8.6 out of 10, Excellent, (1650)
"Decent room, great staff and close to am"
United States
siva
The price is 3.111.660 ₫
3.576.698 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Sheraton Mission Valley San Diego Hotel
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1057)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.565.224 ₫
4.898.165 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Hypo-allergenic bedding, in-room safe, desk, iron/ironing board
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (2868)
"It was nice and the bar up top was great"
United States
Brent
The price is 4.639.712 ₫
6.815.895 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Manchester Grand Hyatt San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1941)
"Great hotel"
United States
Farzana
The price is 4.192.830 ₫
6.248.174 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Marriott Marquis San Diego Marina
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1160)
"Amenities and location were great. "
United States
Julie
The price is 4.248.207 ₫
5.995.678 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
Property amenity
San Diego Marriott Mission Valley

San Diego Marriott Mission Valley

San Diego Marriott Mission Valley
4.0 star property
Mission Valley
8.8 out of 10, Excellent, (1005)
"Great room and staff"
United States
Mario
The price is 3.665.430 ₫
4.213.228 ₫ total
includes taxes & fees
14 Dec - 15 Dec
San Diego Marriott Mission Valley
Lobby sitting area
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (2048)
"It was an amazing stay "
United States
Alejandra
The price is 4.909.000 ₫
6.884.191 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Omni San Diego Hotel at the Ballpark
Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.2 out of 10, Very good, (3172)
"Great stay! "
United States
Melissa
The price is 2.478.780 ₫
3.798.554 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Sheraton San Diego Resort
Exterior
InterContinental San Diego by IHG

InterContinental San Diego by IHG

InterContinental San Diego by IHG
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1113)
"Excellent location prior to a cruise."
Canada
Joan
The price is 5.669.550 ₫
8.103.020 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
InterContinental San Diego by IHG
Property grounds
Paradise Point Resort & Spa

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay
8.6 out of 10, Excellent, (2352)
"Amazing place!"
United States
Barak Ben
The price is 3.410.959 ₫
5.316.227 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Paradise Point Resort & Spa
View from property
Courtyard by Marriott San Diego Downtown

Courtyard by Marriott San Diego Downtown

Courtyard by Marriott San Diego Downtown
4.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (1000)
"Great place. Friendly staff. "
United States
Douglas Steven
The price is 3.612.690 ₫
4.188.734 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Courtyard by Marriott San Diego Downtown
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Otay Mesa.
Pendry San Diego

Pendry San Diego

550 J Street San Diego CA
The price is 6.724.350 ₫ per night from 4 Jan to 5 Jan
6.724.350 ₫
9.181.500 ₫ total
4 Jan - 5 Jan 2026
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
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PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Otay Mesa Hotel Reviews

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Hotel was great, no regrets at all."
Gabriel 2-night trip
Posted 5 days ago
Courtyard by Marriott San Diego Downtown Little Italy

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Otay Mesa?
To book a 4-star hotel in Otay Mesa that fits your budget, take advantage of Expedia's handy filters. Browse the availability during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the most economical stay first.

  • Search for the lowest price from 7.522.905 ₫

What's the difference between 5-star and 4-star hotels in Otay Mesa?
Treat yourself to refined living during your Otay Mesa escape by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are usually filled with amenities, including large beds, complimentary bathrobes and plenty more. A 5-star hotel will go the extra mile to make your stay an even more lavish and memorable one. Concierge assistance, elegant décor and world-class dining are a few of the exclusive conveniences and services you'll likely be able to enjoy.
Does Otay Mesa have any 4-star all-inclusive resorts?
Finding your dream hotel in Otay Mesa is as easy as entering your travel dates and destination, and selecting our "All inclusive" filter. Stay and play where everything is already taken care of like your room, meals and activities, or choose a standard 4-star resort in or around this popular destination.

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