Compare and book 4 Star hotels in Otay Mesa, San Diego
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Otay Mesa 4 Star Hotels
Top Otay Mesa 4 Star Hotels

Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
9.0 out of 10, Wonderful, (2782)
The price is 4.936.680 ₫
7.152.178 ₫ total
includes taxes & fees
2 Jul - 3 Jul

Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
9.2 out of 10, Wonderful, (1729)
The price is 6.419.370 ₫
8.628.183 ₫ total
includes taxes & fees
20 Jul - 21 Jul

Embassy Suites by Hilton San Diego Bay Downtown
Embassy Suites by Hilton San Diego Bay Downtown
9.0 out of 10, Wonderful, (1217)
The price is 5.168.115 ₫
6.727.790 ₫ total
includes taxes & fees
6 Jul - 7 Jul

DoubleTree by Hilton Hotel San Diego - Mission Valley
DoubleTree by Hilton Hotel San Diego - Mission Valley
8.2 out of 10, Very good, (1145)
The price is 3.748.547 ₫
4.308.768 ₫ total
includes taxes & fees
6 Jul - 7 Jul

Sheraton Mission Valley San Diego Hotel
Sheraton Mission Valley San Diego Hotel
8.4 out of 10, Very good, (1413)
The price is 3.966.440 ₫
4.559.224 ₫ total
includes taxes & fees
2 Jul - 3 Jul

Wyndham San Diego Bayside
Wyndham San Diego Bayside
8.4 out of 10, Very good, (5717)
The price is 3.970.354 ₫
5.360.174 ₫ total
includes taxes & fees
2 Jul - 3 Jul

Lafayette Hotel & Club
Lafayette Hotel & Club
9.2 out of 10, Wonderful, (919)
The price is 6.367.180 ₫
7.306.340 ₫ total
includes taxes & fees
2 Jul - 3 Jul

Palihotel San Diego Gaslamp Quarter
Palihotel San Diego Gaslamp Quarter
8.6 out of 10, Excellent, (1464)
The price is 3.029.629 ₫
4.248.060 ₫ total
includes taxes & fees
27 Jul - 28 Jul
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Otay Mesa.

Pendry San Diego
550 J Street, San Diego, CA
The price is 6.915.175 ₫ per night from 20 Jul to 21 Jul
6.915.175 ₫
9.342.382 ₫ total
20 Jul - 21 Jul
includes taxes & fees
9.2/10 Wonderful! (1,000 reviews)
Still don't see what you're looking for?
See all properties in Otay Mesa.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Otay Mesa by Star Rating
Areas of Otay Mesa
Accommodation near Otay Mesa attractions
- Hotels near Cross Border Xpress
- Hotels near San Diego Zoo
- Hotels near Mission Bay
- Hotels near San Diego Convention Center
- Hotels near San Ysidro Border Crossing
- Hotels near Mission Beach
- Hotels near Balboa Park
- Hotels near Petco Park
- Hotels near Hotel Circle
- Hotels near Naval Base San Diego
- Hotels near San Diego State University
- Hotels near Marine Corps Recruit Depot
- Hotels near Naval Base Coronado
- Hotels near Coronado Beach
- Hotels near Seaport Village
- Hotels near B Street Cruise Ship Terminal
- Hotels near Las Americas Premium Outlets
Choose Your Otay Mesa Hotel Style
- Beach Resorts & Hotels in Otay Mesa
- Business Hotels in Otay Mesa
- Casino Hotels in Otay Mesa
- Cheap Hotels in Otay Mesa
- Family-Friendly Hotels in Otay Mesa
- Golf Hotels in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels Suites in Otay Mesa
- Hotels near Museums in Otay Mesa
- Hotels with Air Conditioning in Otay Mesa
- Hotels with Breakfast in Otay Mesa
- Hotels with Connecting Rooms in Otay Mesa
- Hotels with Entertainment in Otay Mesa
- Hotels with Gym in Otay Mesa
- Hotels with Laundry Service in Otay Mesa
- Hotels with Parking in Otay Mesa
- Hotels with Wifi in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Shopping Hotels in Otay Mesa
- Spa Hotels in Otay Mesa
Recommended cities for you
More ways to book
Expedia's Latest Trends
Packages