Compare and book 4 Star hotels in Otay Mesa, San Diego

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Otay Mesa 4 Star Hotels

Tonight
27 Nov - 28 Nov
Tomorrow
28 Nov - 29 Nov
This weekend
28 Nov - 30 Nov
Next weekend
5 Dec - 7 Dec

Top Otay Mesa 4 Star Hotels

Lobby
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4.0 star property
Historic Downtown Coronado
8.4 out of 10, Very good, (1015)
"Fantastic hotel and location"
United Kingdom
edward
The price is 10.064.874 ₫
12.637.766 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hotel del Coronado, Curio Collection by Hilton
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (3106)
"Our stay was great! Would stay here again"
United States
Carla
The price is 6.859.097 ₫
9.160.230 ₫ total
includes taxes & fees
28 Nov - 29 Nov
Hard Rock Hotel San Diego
Daily buffet breakfast for a fee
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4.0 star property
Mission Valley
8.4 out of 10, Very good, (1365)
"Great hotel ."
United States
Matthew
The price is 2.897.645 ₫
3.330.698 ₫ total
includes taxes & fees
28 Dec - 29 Dec
DoubleTree by Hilton Hotel San Diego - Mission Valley
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4.0 star property
Downtown San Diego
8.2 out of 10, Very good, (1256)
"Beautiful hotel ."
United States
Emiliano
The price is 3.003.657 ₫
3.482.590 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Courtyard by Marriott San Diego Downtown Little Italy
Lobby
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4.0 star property
Mission Valley
8.0 out of 10, Very good, (2214)
"Very good place to stay at"
Canada
Shan
The price is 3.005.767 ₫
3.454.978 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Hilton San Diego Mission Valley
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2966)
"Great stay"
United States
Songkwon
The price is 3.304.412 ₫
3.798.257 ₫ total
includes taxes & fees
30 Nov - 1 Dec
Legacy Resort Hotel & Spa
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
Downtown San Diego
8.4 out of 10, Very good, (6069)
"I enjoyed my stay."
United States
Kevin
The price is 3.564.041 ₫
4.897.087 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Wyndham San Diego Bayside
Lobby
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1537)
"Hotel was in a great location"
United States
Holly
The price is 4.367.038 ₫
6.020.102 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Embassy Suites by Hilton San Diego Bay Downtown
Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)
Lafayette Hotel & Club

Lafayette Hotel & Club

4.0 star property
University Heights
9.4 out of 10, Exceptional, (1293)
"Loved everything, I could stay there forever"
United States
Mariana
The price is 5.959.846 ₫
6.838.923 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Lafayette Hotel & Club
Outdoor pool
Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel

4.0 star property
Mission Valley
8.6 out of 10, Excellent, (1629)
"The room was a great size and super clean, the staff is super nice "
United States
Ligia
The price is 3.111.778 ₫
3.576.833 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Sheraton Mission Valley San Diego Hotel
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1036)
"Spacious rooms , great staff "
United States
Jessica
The price is 3.119.689 ₫
4.381.618 ₫ total
includes taxes & fees
28 Dec - 29 Dec
The Westin San Diego Bayview
6 restaurants, breakfast, lunch, dinner served; seafood
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (2878)
"the best best best hotel"
China
cong
The price is 4.236.501 ₫
6.346.593 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Manchester Grand Hyatt San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1931)
"Great hotel"
United States
Farzana
The price is 4.192.989 ₫
6.248.411 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Marriott Marquis San Diego Marina
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1140)
"Great Hotel - good position and very helpful staff. "
United Kingdom
James
The price is 4.236.501 ₫
5.982.147 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
Property amenity
San Diego Marriott Mission Valley

San Diego Marriott Mission Valley

4.0 star property
Mission Valley
8.8 out of 10, Excellent, (1011)
"Great location, hotel is under construction so part of the hotel is completely closed off for construction. "
United States
Amama
The price is 3.339.887 ₫
3.839.034 ₫ total
includes taxes & fees
15 Dec - 16 Dec
San Diego Marriott Mission Valley
Lobby sitting area
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (2065)
"It was an amazing stay "
United States
Alejandra
The price is 4.684.986 ₫
6.624.647 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Omni San Diego Hotel at the Ballpark
Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

4.0 star property
Harbor Island
8.2 out of 10, Very good, (3170)
"This was a great stay for a small vacation."
United States
George Edmond Junior
The price is 2.953.552 ₫
4.344.317 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Sheraton San Diego Resort
Exterior
InterContinental San Diego by IHG

InterContinental San Diego by IHG

4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1103)
"Really a good place "
Canada
Mehdi
The price is 5.253.302 ₫
7.620.517 ₫ total
includes taxes & fees
14 Dec - 15 Dec
InterContinental San Diego by IHG
Property grounds
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4.0 star property
Mission Bay
8.6 out of 10, Excellent, (2351)
"Great place to stay"
United States
Manuel
The price is 3.411.089 ₫
5.316.393 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Paradise Point Resort & Spa
View from property
Courtyard by Marriott San Diego Downtown

Courtyard by Marriott San Diego Downtown

4.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (1014)
"It was a good stay, the room seemed clean and "
United States
Soraya Lizbeth
The price is 3.564.041 ₫
4.132.327 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Courtyard by Marriott San Diego Downtown
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Otay Mesa.
Pendry San Diego

Pendry San Diego

550 J Street San Diego CA
The price is 6.724.605 ₫ per night from 18 Dec to 19 Dec
6.724.605 ₫
9.181.849 ₫ total
18 Dec - 19 Dec
includes taxes & fees
9.2/10 Wonderful! (1,003 reviews)
Still don't see what you're looking for?
See all properties in Otay Mesa.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Otay Mesa Hotel Reviews

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"I always have great stay here"
Brandon 1-night trip
Posted 4 days ago
Courtyard by Marriott San Diego Downtown Little Italy

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Otay Mesa?
To book a 4-star hotel in Otay Mesa that fits your budget, take advantage of Expedia's handy filters. Browse the availability during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the most economical stay first.

  • Search for the lowest price from 7.510.958 ₫

What's the difference between 5-star and 4-star hotels in Otay Mesa?
Treat yourself to refined living during your Otay Mesa escape by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are usually filled with amenities, including large beds, complimentary bathrobes and plenty more. A 5-star hotel will go the extra mile to make your stay an even more lavish and memorable one. Concierge assistance, elegant décor and world-class dining are a few of the exclusive conveniences and services you'll likely be able to enjoy.
Does Otay Mesa have any 4-star all-inclusive resorts?
Finding your dream hotel in Otay Mesa is as easy as entering your travel dates and destination, and selecting our "All inclusive" filter. Stay and play where everything is already taken care of like your room, meals and activities, or choose a standard 4-star resort in or around this popular destination.

Explore a world of travel with Expedia