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Our top choices for Otay Mesa hotels with a spa

Fitness studio
Sycuan Casino Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1627)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
Hot stone massages, prenatal massages, sports massages, body scrubs
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1309)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is 3.101.165 ₫
4.752.695 ₫ total
includes taxes & fees
14 Dec - 15 Dec
San Diego Mission Bay Resort
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very good, (1570)
"Loved our stay "
United States
Jeremy
The price is 3.060.048 ₫
4.911.921 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Hyatt Regency Mission Bay Spa and Marina
Body treatments, aromatherapy, body wraps, body scrubs, facials
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1856)
"Enjoyed my stay"
United States
Brandon
The price is 2.490.737 ₫
4.181.374 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton San Diego Bayfront
Exterior
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
Point Loma
8.8 out of 10, Excellent, (1554)
"Every time i have stayed here everything is always clean...no complaints!"
United States
Joseline
The price is 3.015.241 ₫
3.465.869 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Island Palms Hotel & Marina
Couples treatment room(s), sauna, hot tub, steam room, body treatments
Loews Coronado Bay Resort

Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
Silver Strand
8.8 out of 10, Excellent, (1066)
"My stay was wonderful! "
United States
Jeanine
The price is 4.717.903 ₫
6.516.504 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Loews Coronado Bay Resort
Water view
Kona Kai San Diego

Kona Kai San Diego

Kona Kai San Diego
4.0 star property
Point Loma
8.2 out of 10, Very good, (1000)
"had a wonderful time for our honey moon here "
United States
Anna
The price is 3.969.646 ₫
6.145.110 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Kona Kai San Diego
Front of property – evening/night
Handlery Hotel

Handlery Hotel

Handlery Hotel
3.5 star property
Mission Valley
8.2 out of 10, Very good, (2220)
"Staff was amazing and very accommodating. Always recommended staying here. "
United States
Taja
Handlery Hotel
Facials, 2 treatment rooms, massages
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1060)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.563.466 ₫
4.895.750 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Couples treatment room(s), body treatments, hot stone massages
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (2941)
"Everything was super comfortable and the room was surprisingly affordable for the amenities you get. We will definitely stay there again if we go to San Diego."
United States
Eric
The price is 4.010.218 ₫
4.609.544 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Legacy Resort Hotel & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Leigh at the front desk."
Randolph 1-night trip
Posted 2 days ago
Hampton Inn & Suites by Hilton San Diego SeaWorld
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Hotel was great, no regrets at all."
Gabriel 2-night trip
Posted 6 days ago
Courtyard by Marriott San Diego Downtown Little Italy

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Frequently asked questions

Looking for a spa hotel in Otay Mesa?
Treat yourself to some pampering and book a hotel with a spa. Enjoy the theatre scene and shops in Otay Mesa—your day trip starts here. Discover the beaches and many popular restaurants during your stay. Hotels with spas are the perfect way to break away from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Otay Mesa?
Enjoy Otay Mesa with a stop at San Diego Zoo, San Ysidro Border Crossing and Petco Park. If you have spare time during your trip, you might want to make a stop at Port of San Diego and High Performance Center in Tijuana.
What is a Otay Mesa spa hotel?
Spa hotels in Otay Mesa provide lodging and have a full on-site spa which offers services such as massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.