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Check availability on Otay Mesa Spa Hotels

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top Otay Mesa Spa Hotels

Fitness studio
Sycuan Casino Resort

Sycuan Casino Resort

4.0 star property
El Cajon
9.2 out of 10, Wonderful, (1627)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
Exterior
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4.0 star property
Mission Bay
8.4 out of 10, Very good, (1583)
"Loved our stay "
United States
Jeremy
The price is 3.061.905 ₫
4.914.901 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Hyatt Regency Mission Bay Spa and Marina
Body treatments, aromatherapy, body wraps, body scrubs, facials
Hilton San Diego Bayfront

Hilton San Diego Bayfront

4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1840)
"Beautiful hotel, good bar, great staff and right on the bay and close to downtown and not to far away from local beaches. "
United States
Daniel
The price is 2.136.375 ₫
3.772.087 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton San Diego Bayfront
Facials, 2 treatment rooms, massages
The Westin San Diego Bayview

The Westin San Diego Bayview

4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1046)
"Great room in a very convenient location"
Canada
Kristjan
The price is 3.565.630 ₫
4.898.723 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Couples treatment room(s), sauna, hot tub, steam room, body treatments
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4.0 star property
Silver Strand
8.8 out of 10, Excellent, (1064)
"My stay was wonderful! "
United States
Jeanine
The price is 4.720.767 ₫
6.520.461 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Loews Coronado Bay Resort
Premier Room, 1 King Bed | Premium bedding, in-room safe, desk, blackout curtains
Handlery Hotel

Handlery Hotel

3.5 star property
Mission Valley
8.2 out of 10, Very good, (2229)
"Staff was amazing and very accommodating. Always recommended staying here. "
United States
Taja
The price is 2.196.871 ₫
2.525.194 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Handlery Hotel
Reception
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

3.0 star property
Point Loma
8.8 out of 10, Excellent, (1563)
"Nice hotel "
United States
Anthony
The price is 3.038.170 ₫
3.492.225 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Best Western Plus Island Palms Hotel & Marina
Hot stone massages, prenatal massages, sports massages, body scrubs
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4.0 star property
Mission Bay
8.4 out of 10, Very good, (1305)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is 4.227.592 ₫
6.048.384 ₫ total
includes taxes & fees
19 Dec - 20 Dec
San Diego Mission Bay Resort
Couples treatment room(s), steam room, body treatments, aromatherapy
Coronado Island Marriott Resort & Spa

Coronado Island Marriott Resort & Spa

4.0 star property
Bayside
8.4 out of 10, Very good, (1002)
"Excellent service and staff. "
United States
Michelle
The price is 5.133.504 ₫
7.199.076 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Coronado Island Marriott Resort & Spa
Property grounds
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4.0 star property
Mission Bay
8.6 out of 10, Excellent, (2346)
"Amazing place!"
United States
Barak Ben
The price is 3.411.348 ₫
5.316.797 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Paradise Point Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Very clean!"
Franco 3-night trip
Posted 2 days ago
Hampton Inn & Suites by Hilton San Diego SeaWorld
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Nice staff and clean room"
Aida 1-night trip
Posted 5 days ago
Courtyard by Marriott San Diego Downtown Little Italy

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Frequently asked questions

Looking for a spa hotel in Otay Mesa?
Treat yourself to some pampering and book a hotel with a spa. Enjoy the theatre scene and shops in Otay Mesa—your day trip starts here. Discover the beaches and many popular restaurants during your stay. Hotels with spas are the perfect way to break away from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Otay Mesa?
Enjoy Otay Mesa with a stop at San Diego Zoo, San Ysidro Border Crossing and Petco Park. If you have spare time during your trip, you might want to make a stop at Port of San Diego and High Performance Center in Tijuana.
What is a Otay Mesa spa hotel?
Spa hotels in Otay Mesa provide lodging and have a full on-site spa which offers services such as massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.